T follicular helper and TH2 cells in allergic responses
IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE)....
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893017300473 |
| _version_ | 1818848029216604160 |
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| author | Masato Kubo |
| author_facet | Masato Kubo |
| author_sort | Masato Kubo |
| collection | DOAJ |
| description | IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by TH2 and TFH cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting TFH cells, but not by TH2 cells. In this review, we discuss the role of TH2 and TFH cells in IgE production and allergic responses. |
| first_indexed | 2024-12-19T06:10:50Z |
| format | Article |
| id | doaj.art-bb9bdb165d0c44368467421a72324553 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-19T06:10:50Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-bb9bdb165d0c44368467421a723245532022-12-21T20:33:01ZengElsevierAllergology International1323-89302017-07-0166337738110.1016/j.alit.2017.04.006T follicular helper and TH2 cells in allergic responsesMasato Kubo0Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda, JapanIL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by TH2 and TFH cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting TFH cells, but not by TH2 cells. In this review, we discuss the role of TH2 and TFH cells in IgE production and allergic responses.http://www.sciencedirect.com/science/article/pii/S1323893017300473Allergen-specific T cellIL-4Immunoglobulin E (IgE)Th2Th2 cytokines |
| spellingShingle | Masato Kubo T follicular helper and TH2 cells in allergic responses Allergology International Allergen-specific T cell IL-4 Immunoglobulin E (IgE) Th2 Th2 cytokines |
| title | T follicular helper and TH2 cells in allergic responses |
| title_full | T follicular helper and TH2 cells in allergic responses |
| title_fullStr | T follicular helper and TH2 cells in allergic responses |
| title_full_unstemmed | T follicular helper and TH2 cells in allergic responses |
| title_short | T follicular helper and TH2 cells in allergic responses |
| title_sort | t follicular helper and th2 cells in allergic responses |
| topic | Allergen-specific T cell IL-4 Immunoglobulin E (IgE) Th2 Th2 cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S1323893017300473 |
| work_keys_str_mv | AT masatokubo tfollicularhelperandth2cellsinallergicresponses |