Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment
Prostate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant. However, this is a heterogeneous disease, ranging widely in prognosis. Therefore, new approaches are needed base...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/18/4412 |
| _version_ | 1797490290362155008 |
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| author | Luis O. González Noemi Eiro Maria Fraile Nana Beridze Andres R. Escaf Safwan Escaf Jesús M. Fernández-Gómez Francisco J. Vizoso |
| author_facet | Luis O. González Noemi Eiro Maria Fraile Nana Beridze Andres R. Escaf Safwan Escaf Jesús M. Fernández-Gómez Francisco J. Vizoso |
| author_sort | Luis O. González |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant. However, this is a heterogeneous disease, ranging widely in prognosis. Therefore, new approaches are needed based on tumor biology, from which further prognostic assessments can be established and complementary strategies can be identified. The knowledge of both the morphological structure and functional biology of the PCa stroma compartment can provide new diagnostic, prognostic or therapeutic possibilities. In the present review, we analyzed the aspects related to the tumor stromal component (both acellular and cellular) in PCa, their influence on tumor behavior and the therapeutic response and their consideration as a new therapeutic target. |
| first_indexed | 2024-03-10T00:30:52Z |
| format | Article |
| id | doaj.art-bb9ca6a702fa434c8399978328d3d576 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:30:52Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bb9ca6a702fa434c8399978328d3d5762023-11-23T15:26:50ZengMDPI AGCancers2072-66942022-09-011418441210.3390/cancers14184412Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and TreatmentLuis O. González0Noemi Eiro1Maria Fraile2Nana Beridze3Andres R. Escaf4Safwan Escaf5Jesús M. Fernández-Gómez6Francisco J. Vizoso7Department of Anatomical Pathology, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainDepartment of Urology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Avda. de Roma s/n., 33011 Oviedo, SpainDepartment of Urology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Avda. de Roma s/n., 33011 Oviedo, SpainResearch Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33920 Gijón, SpainProstate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant. However, this is a heterogeneous disease, ranging widely in prognosis. Therefore, new approaches are needed based on tumor biology, from which further prognostic assessments can be established and complementary strategies can be identified. The knowledge of both the morphological structure and functional biology of the PCa stroma compartment can provide new diagnostic, prognostic or therapeutic possibilities. In the present review, we analyzed the aspects related to the tumor stromal component (both acellular and cellular) in PCa, their influence on tumor behavior and the therapeutic response and their consideration as a new therapeutic target.https://www.mdpi.com/2072-6694/14/18/4412cancer-associated fibroblastsmesenchymal stromal cellstumor microenvironmentextracellular vesiclesexosomesbiochemical recurrence in prostate cancer |
| spellingShingle | Luis O. González Noemi Eiro Maria Fraile Nana Beridze Andres R. Escaf Safwan Escaf Jesús M. Fernández-Gómez Francisco J. Vizoso Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment Cancers cancer-associated fibroblasts mesenchymal stromal cells tumor microenvironment extracellular vesicles exosomes biochemical recurrence in prostate cancer |
| title | Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment |
| title_full | Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment |
| title_fullStr | Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment |
| title_full_unstemmed | Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment |
| title_short | Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment |
| title_sort | prostate cancer tumor stroma responsibility in tumor biology diagnosis and treatment |
| topic | cancer-associated fibroblasts mesenchymal stromal cells tumor microenvironment extracellular vesicles exosomes biochemical recurrence in prostate cancer |
| url | https://www.mdpi.com/2072-6694/14/18/4412 |
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