Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-canonical functions is unknown. Here we demon...

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Bibliographic Details
Main Authors: Marvin E Tanenbaum, Ronald D Vale, Richard J McKenney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-09-01
Series:eLife
Subjects:
dynein
spindle
microtubule
Eg5
cytoskeleton
mitosis
Online Access:https://elifesciences.org/articles/00943

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