Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is conv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
1972-05-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520393925 |
| _version_ | 1818596142851555328 |
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| author | L.W. Parks F.T. Bond E.D. Thompson P.R. Starr |
| author_facet | L.W. Parks F.T. Bond E.D. Thompson P.R. Starr |
| author_sort | L.W. Parks |
| collection | DOAJ |
| description | Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis. |
| first_indexed | 2024-12-16T11:27:13Z |
| format | Article |
| id | doaj.art-bb9f086348a947f2b77cfa99bc1a14cb |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T11:27:13Z |
| publishDate | 1972-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-bb9f086348a947f2b77cfa99bc1a14cb2022-12-21T22:33:19ZengElsevierJournal of Lipid Research0022-22751972-05-01133311316Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeastL.W. Parks0F.T. Bond1E.D. Thompson2P.R. Starr3Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; and; Department of Chemistry, Revelle College, University of California at San Diego, LaJolla, California 92037Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(9),22-ergostadiene-3β-ol. This sterol is converted to ergosterol by wild-type yeasts and is observed transiently in cells during aerobic adaption of anaerobically grown wild-type yeasts. The new sterol is proposed as an intermediate in ergosterol biosynthesis.http://www.sciencedirect.com/science/article/pii/S0022227520393925ergosterolsterol mutantyeast sterolpolyene resistance |
| spellingShingle | L.W. Parks F.T. Bond E.D. Thompson P.R. Starr Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast Journal of Lipid Research ergosterol sterol mutant yeast sterol polyene resistance |
| title | Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast |
| title_full | Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast |
| title_fullStr | Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast |
| title_full_unstemmed | Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast |
| title_short | Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast |
| title_sort | δ8 9 22 ergostadiene 3β ol an ergosterol precursor accumulated in wild type and mutants of yeast |
| topic | ergosterol sterol mutant yeast sterol polyene resistance |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520393925 |
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