Generation of induced pluripotent stem cells from three individuals with Huntington‘s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal glutamine (Q) expansion in the huntingtin protein due to elongated CAG repeats in the gene HTT. We used non-integrative episomal plasmids to generate induced pluripotent stem cells (iPSCs) from three individuals affected by...
Main Authors: | Duncan C. Miller, Pawel Lisowski, Selene Lickfett, Barbara Mlody, Miriam Bünning, Carolin Genehr, Claas Ulrich, Erich E. Wanker, Sebastian Diecke, Josef Priller, Alessandro Prigione |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
|
Series: | Stem Cell Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506122003257 |
Similar Items
-
Generation of an induced pluripotent stem cell line from a Huntington’s disease patient with a long HTT-PolyQ sequence
by: Duncan C. Miller, et al.
Published: (2023-04-01) -
Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6
by: Carmen Lorenz, et al.
Published: (2022-05-01) -
High-content analysis of neuronal morphology in human iPSC-derived neurons
by: Selene Lickfett, et al.
Published: (2022-09-01) -
RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease
by: Miguel A. Andrade-Navarro, et al.
Published: (2020-11-01) -
Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
by: Franziska Schindler, et al.
Published: (2021-06-01)