THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
The study aimed to evaluate the effectiveness of pharmacological preconditioning and postconditioning with sublingual adenosine in prevention of reperfusion damage in patients with ST-segment elevation myocardial infarction.Material and methods. In prospective trial 166 patients with STEMI were rand...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
SINAPS LLC
2018-02-01
|
| Series: | Архивъ внутренней медицины |
| Subjects: | |
| Online Access: | https://www.medarhive.ru/jour/article/view/744 |
| _version_ | 1797883799996989440 |
|---|---|
| author | N. T. Vatutin A. N. Shevelok V. S. Kolesnikov |
| author_facet | N. T. Vatutin A. N. Shevelok V. S. Kolesnikov |
| author_sort | N. T. Vatutin |
| collection | DOAJ |
| description | The study aimed to evaluate the effectiveness of pharmacological preconditioning and postconditioning with sublingual adenosine in prevention of reperfusion damage in patients with ST-segment elevation myocardial infarction.Material and methods. In prospective trial 166 patients with STEMI were randomized to sublingual adenosine prior and after percutaneous coronary intervention (n=82) or standard therapy (n=84). Reperfusion arrhythmia, blood level of troponin T and effectiveness of reperfusion was assessed.Results. According to PCI results angiographic success was achieved in 88.1% patients of adenosine group and 92.7% patients of standard therapy group (p > 0.05). The reperfusion arrhythmias rate was significantly low in adenosine group (78%) compared to control (92.9%, p = 0.013). The use of adenosine was associated with 25.4% risk reduction in life-threatening reperfusion arrhythmias (p<0.01). During 24 h after PCI troponin T level decreased in both groups more significantly in adenosine (p < 0.05). The use of adenosine was associated with 8.3% risk reduction in myocardial reperfusion damage (p < 0.05).Conclusions. The pharmacological preconditioning and postconditioning with sublingual adenosine in the perioperative period of PCI in patients with STEMI is usefull to prevent myocardial reperfusion damage but does not affect the efficiency of reperfusion. |
| first_indexed | 2024-04-10T03:56:27Z |
| format | Article |
| id | doaj.art-bb9fa5610ea3493da33ba78bee97fb96 |
| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2024-04-10T03:56:27Z |
| publishDate | 2018-02-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-bb9fa5610ea3493da33ba78bee97fb962023-03-13T07:12:08ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642018-02-0181293510.20514/2226-6704-2018-8-1-29-35653THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTIONN. T. Vatutin0A. N. Shevelok1V. S. Kolesnikov2Донецкий национальный медицинский университет им.М.Горького Институт неотложной и восстановительной хирургии им. В.К. ГусакаДонецкий национальный медицинский университет им.М.Горького Институт неотложной и восстановительной хирургии им. В.К. ГусакаИнститут неотложной и восстановительной хирургии им. В.К. ГусакаThe study aimed to evaluate the effectiveness of pharmacological preconditioning and postconditioning with sublingual adenosine in prevention of reperfusion damage in patients with ST-segment elevation myocardial infarction.Material and methods. In prospective trial 166 patients with STEMI were randomized to sublingual adenosine prior and after percutaneous coronary intervention (n=82) or standard therapy (n=84). Reperfusion arrhythmia, blood level of troponin T and effectiveness of reperfusion was assessed.Results. According to PCI results angiographic success was achieved in 88.1% patients of adenosine group and 92.7% patients of standard therapy group (p > 0.05). The reperfusion arrhythmias rate was significantly low in adenosine group (78%) compared to control (92.9%, p = 0.013). The use of adenosine was associated with 25.4% risk reduction in life-threatening reperfusion arrhythmias (p<0.01). During 24 h after PCI troponin T level decreased in both groups more significantly in adenosine (p < 0.05). The use of adenosine was associated with 8.3% risk reduction in myocardial reperfusion damage (p < 0.05).Conclusions. The pharmacological preconditioning and postconditioning with sublingual adenosine in the perioperative period of PCI in patients with STEMI is usefull to prevent myocardial reperfusion damage but does not affect the efficiency of reperfusion.https://www.medarhive.ru/jour/article/view/744острый инфаркт миокардафармакологическое прекондиционированиеаденозинреперфузионное повреждение |
| spellingShingle | N. T. Vatutin A. N. Shevelok V. S. Kolesnikov THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION Архивъ внутренней медицины острый инфаркт миокарда фармакологическое прекондиционирование аденозин реперфузионное повреждение |
| title | THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_full | THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_fullStr | THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_full_unstemmed | THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_short | THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_sort | effectiveness of preconditioning and postconditioning with adenosine in prevention of reperfusion damage in patients with st segment elevation myocardial infarction |
| topic | острый инфаркт миокарда фармакологическое прекондиционирование аденозин реперфузионное повреждение |
| url | https://www.medarhive.ru/jour/article/view/744 |
| work_keys_str_mv | AT ntvatutin theeffectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction AT anshevelok theeffectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction AT vskolesnikov theeffectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction AT ntvatutin effectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction AT anshevelok effectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction AT vskolesnikov effectivenessofpreconditioningandpostconditioningwithadenosineinpreventionofreperfusiondamageinpatientswithstsegmentelevationmyocardialinfarction |