A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator
BackgroundNon-suicidal self-injury (NSSI) behaviors are common in adolescents with major depressive disorder (MDD). Brain studies specifically targeting adolescents with MDD and NSSI may provide new insights into suicide warnings in adolescents with MDD.MethodsThis study examined the whole-brain neu...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.925672/full |
| _version_ | 1811245281813987328 |
|---|---|
| author | Yi Zhou Renqiang Yu Ming Ai Jun Cao Xiao Li Su Hong Qian Huang Linqi Dai LiXia Wang Lin Zhao Qi Zhang Lei Shi Li Kuang |
| author_facet | Yi Zhou Renqiang Yu Ming Ai Jun Cao Xiao Li Su Hong Qian Huang Linqi Dai LiXia Wang Lin Zhao Qi Zhang Lei Shi Li Kuang |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | BackgroundNon-suicidal self-injury (NSSI) behaviors are common in adolescents with major depressive disorder (MDD). Brain studies specifically targeting adolescents with MDD and NSSI may provide new insights into suicide warnings in adolescents with MDD.MethodsThis study examined the whole-brain neural activity in adolescents aged between 12–17 years, 50 unmedicated MDD patients with (nsMDDs) or without NSSI (nnsMDDs), and 25 healthy controls (HCs) participated in this study, and analyzed the correlation between the values of amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in significantly different brain regions and the scores of the relevant clinical psychological scale.ResultsCompared with nnsMDDs, nsMDDs had enhanced ALFF values in left middle occipital gyrus and left median cingulate and paracingulate gyri; the fALFF values of the right caudate nucleus was weakened in the nsMDDs; the ReHo values of right middle occipital gyrus and right middle temporal gyrus weakened and the ReHo values of right medial cingulate gyrus enhanced in nsMDDs. And all of differences were statistically significant. In nsMDDs, the value of ALFF in the left calcarine fissure and surrounding cortex was negatively correlated with the score of Children's depression Inventory (CDI); the value of fALFF in the right caudate nucleus was positively correlated with the score of Beck Scale for Suicidal Ideations (BSSI); the value of ReHo in the right middle temporal gyrus was positively correlated with the score of Multidimensional Anxiety Scale for Children (MASC); and the value of ReHo in the right median cingulate and paracingulate gyri was negatively correlated with the score of BSSI.ConclusionsWe found that in ALFF, fALFF and ReHo, the significant differences between nsMDDs and nnsMDDs are mainly located in default mode network (DMN) and visual network (VN), and there may be brain regions related to NSSI in DMN and VN. The significant differences brain regions in ALFF, fALFF and ReHo between nsMDDs and nnsMDDs were related to the total score of the relevant clinical psychological scale, and may be related to NSSI. |
| first_indexed | 2024-04-12T14:38:20Z |
| format | Article |
| id | doaj.art-bba01b348cd9483cad44115fec133666 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T14:38:20Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-bba01b348cd9483cad44115fec1336662022-12-22T03:29:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-06-011310.3389/fpsyt.2022.925672925672A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity IndicatorYi Zhou0Renqiang Yu1Ming Ai2Jun Cao3Xiao Li4Su Hong5Qian Huang6Linqi Dai7LiXia Wang8Lin Zhao9Qi Zhang10Lei Shi11Li Kuang12Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundNon-suicidal self-injury (NSSI) behaviors are common in adolescents with major depressive disorder (MDD). Brain studies specifically targeting adolescents with MDD and NSSI may provide new insights into suicide warnings in adolescents with MDD.MethodsThis study examined the whole-brain neural activity in adolescents aged between 12–17 years, 50 unmedicated MDD patients with (nsMDDs) or without NSSI (nnsMDDs), and 25 healthy controls (HCs) participated in this study, and analyzed the correlation between the values of amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in significantly different brain regions and the scores of the relevant clinical psychological scale.ResultsCompared with nnsMDDs, nsMDDs had enhanced ALFF values in left middle occipital gyrus and left median cingulate and paracingulate gyri; the fALFF values of the right caudate nucleus was weakened in the nsMDDs; the ReHo values of right middle occipital gyrus and right middle temporal gyrus weakened and the ReHo values of right medial cingulate gyrus enhanced in nsMDDs. And all of differences were statistically significant. In nsMDDs, the value of ALFF in the left calcarine fissure and surrounding cortex was negatively correlated with the score of Children's depression Inventory (CDI); the value of fALFF in the right caudate nucleus was positively correlated with the score of Beck Scale for Suicidal Ideations (BSSI); the value of ReHo in the right middle temporal gyrus was positively correlated with the score of Multidimensional Anxiety Scale for Children (MASC); and the value of ReHo in the right median cingulate and paracingulate gyri was negatively correlated with the score of BSSI.ConclusionsWe found that in ALFF, fALFF and ReHo, the significant differences between nsMDDs and nnsMDDs are mainly located in default mode network (DMN) and visual network (VN), and there may be brain regions related to NSSI in DMN and VN. The significant differences brain regions in ALFF, fALFF and ReHo between nsMDDs and nnsMDDs were related to the total score of the relevant clinical psychological scale, and may be related to NSSI.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.925672/fullmajor depressive disorder (MDD)non-suicidal self-injury (NSSI)resting-state functional magnetic resonance imaging (rs-fMRI)adolescentsamplitude of low-frequency fluctuation (ALFF)fractional amplitude of low-frequency fluctuation (fALFF) |
| spellingShingle | Yi Zhou Renqiang Yu Ming Ai Jun Cao Xiao Li Su Hong Qian Huang Linqi Dai LiXia Wang Lin Zhao Qi Zhang Lei Shi Li Kuang A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator Frontiers in Psychiatry major depressive disorder (MDD) non-suicidal self-injury (NSSI) resting-state functional magnetic resonance imaging (rs-fMRI) adolescents amplitude of low-frequency fluctuation (ALFF) fractional amplitude of low-frequency fluctuation (fALFF) |
| title | A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator |
| title_full | A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator |
| title_fullStr | A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator |
| title_full_unstemmed | A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator |
| title_short | A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator |
| title_sort | resting state functional magnetic resonance imaging study of unmedicated adolescents with non suicidal self injury behaviors evidence from the amplitude of low frequency fluctuation and regional homogeneity indicator |
| topic | major depressive disorder (MDD) non-suicidal self-injury (NSSI) resting-state functional magnetic resonance imaging (rs-fMRI) adolescents amplitude of low-frequency fluctuation (ALFF) fractional amplitude of low-frequency fluctuation (fALFF) |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.925672/full |
| work_keys_str_mv | AT yizhou arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT renqiangyu arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT mingai arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT juncao arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT xiaoli arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT suhong arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT qianhuang arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT linqidai arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT lixiawang arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT linzhao arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT qizhang arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT leishi arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT likuang arestingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT yizhou restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT renqiangyu restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT mingai restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT juncao restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT xiaoli restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT suhong restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT qianhuang restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT linqidai restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT lixiawang restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT linzhao restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT qizhang restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT leishi restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator AT likuang restingstatefunctionalmagneticresonanceimagingstudyofunmedicatedadolescentswithnonsuicidalselfinjurybehaviorsevidencefromtheamplitudeoflowfrequencyfluctuationandregionalhomogeneityindicator |