New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and multidrug resistance (MDR), persist and have a negative impact on therapeutic outcomes. When compared to monotherapy, combinati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257122000232 |
| _version_ | 1828117426988908544 |
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| author | Krishan Kumar Varsha Rani Mohini Mishra Ruchi Chawla |
| author_facet | Krishan Kumar Varsha Rani Mohini Mishra Ruchi Chawla |
| author_sort | Krishan Kumar |
| collection | DOAJ |
| description | Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and multidrug resistance (MDR), persist and have a negative impact on therapeutic outcomes. When compared to monotherapy, combination cancer therapy has many advantages, like improving efficacy through synergistic effects and overcoming drug resistance. Combination treatment may comprise several chemotherapeutics drugs and combinations of chemotherapeutic drugs with some other therapeutic options such as surgery or radiation. Cancer treatment that utilizes co-delivery strategies with siRNA and chemotherapeutic drugs has been shown to have highly effective antitumor effects in the treatment of many cancers. However, the highly complex mechanisms of chemotherapeutic drugs-siRNA pairs during the co-delivery process have received little attention. The ideal combination of chemotherapeutic drugs with siRNA is very crucial for producing the desirable anticancer effects that would greatly enhance therapeutic efficiency. This review puts an emphasis on the logic for choosing suitable chemotherapeutic drug-siRNA combinations, which may open the way for the co-delivery of chemotherapeutic drugs and siRNA for treating cancer in the clinic. This review summarizes recent breakthrough in the area of diverse mechanism-based chemotherapeutic drugs-siRNA combinations in cancer treatment. |
| first_indexed | 2024-04-11T13:14:02Z |
| format | Article |
| id | doaj.art-bba10dc9d7fe4d509d3228cfda748a03 |
| institution | Directory Open Access Journal |
| issn | 2590-2571 |
| language | English |
| last_indexed | 2024-04-11T13:14:02Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj.art-bba10dc9d7fe4d509d3228cfda748a032022-12-22T04:22:27ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712022-01-013100103New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapyKrishan Kumar0Varsha Rani1Mohini Mishra2Ruchi Chawla3Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., IndiaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., IndiaCorresponding author. Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., India.; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., IndiaChemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and multidrug resistance (MDR), persist and have a negative impact on therapeutic outcomes. When compared to monotherapy, combination cancer therapy has many advantages, like improving efficacy through synergistic effects and overcoming drug resistance. Combination treatment may comprise several chemotherapeutics drugs and combinations of chemotherapeutic drugs with some other therapeutic options such as surgery or radiation. Cancer treatment that utilizes co-delivery strategies with siRNA and chemotherapeutic drugs has been shown to have highly effective antitumor effects in the treatment of many cancers. However, the highly complex mechanisms of chemotherapeutic drugs-siRNA pairs during the co-delivery process have received little attention. The ideal combination of chemotherapeutic drugs with siRNA is very crucial for producing the desirable anticancer effects that would greatly enhance therapeutic efficiency. This review puts an emphasis on the logic for choosing suitable chemotherapeutic drug-siRNA combinations, which may open the way for the co-delivery of chemotherapeutic drugs and siRNA for treating cancer in the clinic. This review summarizes recent breakthrough in the area of diverse mechanism-based chemotherapeutic drugs-siRNA combinations in cancer treatment.http://www.sciencedirect.com/science/article/pii/S2590257122000232siRNAChemotherapeutic drugCombination therapyGene silencingRNA interferenceApoptosis |
| spellingShingle | Krishan Kumar Varsha Rani Mohini Mishra Ruchi Chawla New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy Current Research in Pharmacology and Drug Discovery siRNA Chemotherapeutic drug Combination therapy Gene silencing RNA interference Apoptosis |
| title | New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy |
| title_full | New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy |
| title_fullStr | New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy |
| title_full_unstemmed | New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy |
| title_short | New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy |
| title_sort | new paradigm in combination therapy of sirna with chemotherapeutic drugs for effective cancer therapy |
| topic | siRNA Chemotherapeutic drug Combination therapy Gene silencing RNA interference Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590257122000232 |
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