COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES
Abstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form...
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2014-07-01
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| Series: | Инфекция и иммунитет |
| Subjects: | |
| Online Access: | https://www.iimmun.ru/iimm/article/view/152 |
| _version_ | 1797971302381780992 |
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| author | A. P. Toptygina |
| author_facet | A. P. Toptygina |
| author_sort | A. P. Toptygina |
| collection | DOAJ |
| description | Abstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form germinal centers (GC). Signaling lymphocytic activation molecule (SLAM) interaction between Tfh and activated B-cells is essential for GC development. Within GC, Tfh regulates the fate of antigen-specific GC B cells expressing high-affinity B cell receptors to develop memory B cell (Bm) or long-lived PC. Short-lived PC produce low-affinity IgM and IgG3 early antibodies. Both Bm and long-lived PC have high-affinity class-switched IgA and IgG, predominantly IgG1 antibodies. Measles virus uses human SLAM-molecule as a cellular receptor. SLAM is expressed on dendritic cells and activated B and T-cells. This is an important regulator of the isotype switching and antibody affinity maturation, especially IgG3-IgG1 switching. Development of long-term humoral immunity, charac terized by the formation of high-affinity predominantly IgG1 antibodies, is a critical component of protective immunity to pathogens and the major goal of vaccination. However, the mechanisms involved in the shaping and sustaining of long-term humoral immunity remain poorly understood. |
| first_indexed | 2024-04-11T03:30:29Z |
| format | Article |
| id | doaj.art-bba47ca969fa4de6bdbf1ce95096ae96 |
| institution | Directory Open Access Journal |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| last_indexed | 2024-04-11T03:30:29Z |
| publishDate | 2014-07-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj.art-bba47ca969fa4de6bdbf1ce95096ae962023-01-02T06:38:39ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982014-07-014171410.15789/2220-7619-2014-1-7-14152COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSESA. P. Toptygina0G.N. Gabrichevsky Research Institut for Epidemiology and Microbilogy, MoscowAbstract. T follicular helper cells (Tfh) are a CD4+ Th cell subset promoted the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, Tfh can support either extrafollicularly differentiation into short-lived plasma cells (PC) or enter follicles to form germinal centers (GC). Signaling lymphocytic activation molecule (SLAM) interaction between Tfh and activated B-cells is essential for GC development. Within GC, Tfh regulates the fate of antigen-specific GC B cells expressing high-affinity B cell receptors to develop memory B cell (Bm) or long-lived PC. Short-lived PC produce low-affinity IgM and IgG3 early antibodies. Both Bm and long-lived PC have high-affinity class-switched IgA and IgG, predominantly IgG1 antibodies. Measles virus uses human SLAM-molecule as a cellular receptor. SLAM is expressed on dendritic cells and activated B and T-cells. This is an important regulator of the isotype switching and antibody affinity maturation, especially IgG3-IgG1 switching. Development of long-term humoral immunity, charac terized by the formation of high-affinity predominantly IgG1 antibodies, is a critical component of protective immunity to pathogens and the major goal of vaccination. However, the mechanisms involved in the shaping and sustaining of long-term humoral immunity remain poorly understood.https://www.iimmun.ru/iimm/article/view/152specific humoral immune responset follicular helperigg subclassesslammeaslesrubella |
| spellingShingle | A. P. Toptygina COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES Инфекция и иммунитет specific humoral immune response t follicular helper igg subclasses slam measles rubella |
| title | COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES |
| title_full | COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES |
| title_fullStr | COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES |
| title_full_unstemmed | COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES |
| title_short | COMMON MECHANISMS OF SPECIFIC HUMORAL IMMUNE RESPONSE’ SHAPING AND SUSTAINING BY THE EXAMPLE OF IMMUNE RESPONSE TO MEASLES AND RUBELLA VIRUSES |
| title_sort | common mechanisms of specific humoral immune response shaping and sustaining by the example of immune response to measles and rubella viruses |
| topic | specific humoral immune response t follicular helper igg subclasses slam measles rubella |
| url | https://www.iimmun.ru/iimm/article/view/152 |
| work_keys_str_mv | AT aptoptygina commonmechanismsofspecifichumoralimmuneresponseshapingandsustainingbytheexampleofimmuneresponsetomeaslesandrubellaviruses |