Chronic caffeine consumption curbs rTMS-induced plasticity
BackgroundCaffeine is a widely used psychostimulant. In the brain, caffeine acts as a competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate long-term potentiation (LTP), the cellular basis of learning and memory. Repetitive transcranial magnetic stimulation (...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1137681/full |
| _version_ | 1797900380614426624 |
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| author | Megan Vigne Jamie Kweon Prayushi Sharma Benjamin D. Greenberg Benjamin D. Greenberg Linda L. Carpenter Linda L. Carpenter Joshua C. Brown Joshua C. Brown Joshua C. Brown |
| author_facet | Megan Vigne Jamie Kweon Prayushi Sharma Benjamin D. Greenberg Benjamin D. Greenberg Linda L. Carpenter Linda L. Carpenter Joshua C. Brown Joshua C. Brown Joshua C. Brown |
| author_sort | Megan Vigne |
| collection | DOAJ |
| description | BackgroundCaffeine is a widely used psychostimulant. In the brain, caffeine acts as a competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate long-term potentiation (LTP), the cellular basis of learning and memory. Repetitive transcranial magnetic stimulation (rTMS) is theorized to work through LTP induction and can modulate cortical excitability as measured by motor evoked potentials (MEPs). The acute effects of single caffeine doses diminish rTMS-induced corticomotor plasticity. However, plasticity in chronic daily caffeine users has not been examined.MethodWe conducted a post hoc secondary covariate analysis from two previously published plasticity-inducing pharmaco-rTMS studies combining 10 Hz rTMS and D-cycloserine (DCS) in twenty healthy subjects.ResultsIn this hypothesis-generating pilot study, we observed enhanced MEP facilitation in non-caffeine users compared to caffeine users and placebo.ConclusionThese preliminary data highlight a need to directly test the effects of caffeine in prospective well-powered studies, because in theory, they suggest that chronic caffeine use could limit learning or plasticity, including rTMS effectiveness. |
| first_indexed | 2024-04-10T08:45:05Z |
| format | Article |
| id | doaj.art-bba4d6436e6749b5aec0f11ec8e5038a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T08:45:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-bba4d6436e6749b5aec0f11ec8e5038a2023-02-22T10:38:23ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-02-011410.3389/fpsyt.2023.11376811137681Chronic caffeine consumption curbs rTMS-induced plasticityMegan Vigne0Jamie Kweon1Prayushi Sharma2Benjamin D. Greenberg3Benjamin D. Greenberg4Linda L. Carpenter5Linda L. Carpenter6Joshua C. Brown7Joshua C. Brown8Joshua C. Brown9Neuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, United StatesNeuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United StatesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, United StatesDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, United StatesBackgroundCaffeine is a widely used psychostimulant. In the brain, caffeine acts as a competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate long-term potentiation (LTP), the cellular basis of learning and memory. Repetitive transcranial magnetic stimulation (rTMS) is theorized to work through LTP induction and can modulate cortical excitability as measured by motor evoked potentials (MEPs). The acute effects of single caffeine doses diminish rTMS-induced corticomotor plasticity. However, plasticity in chronic daily caffeine users has not been examined.MethodWe conducted a post hoc secondary covariate analysis from two previously published plasticity-inducing pharmaco-rTMS studies combining 10 Hz rTMS and D-cycloserine (DCS) in twenty healthy subjects.ResultsIn this hypothesis-generating pilot study, we observed enhanced MEP facilitation in non-caffeine users compared to caffeine users and placebo.ConclusionThese preliminary data highlight a need to directly test the effects of caffeine in prospective well-powered studies, because in theory, they suggest that chronic caffeine use could limit learning or plasticity, including rTMS effectiveness.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1137681/fullplasticitytranscranial magnetic stimulationcaffeinelong-term potentiationd-cycloserinemotor evoked potentials |
| spellingShingle | Megan Vigne Jamie Kweon Prayushi Sharma Benjamin D. Greenberg Benjamin D. Greenberg Linda L. Carpenter Linda L. Carpenter Joshua C. Brown Joshua C. Brown Joshua C. Brown Chronic caffeine consumption curbs rTMS-induced plasticity Frontiers in Psychiatry plasticity transcranial magnetic stimulation caffeine long-term potentiation d-cycloserine motor evoked potentials |
| title | Chronic caffeine consumption curbs rTMS-induced plasticity |
| title_full | Chronic caffeine consumption curbs rTMS-induced plasticity |
| title_fullStr | Chronic caffeine consumption curbs rTMS-induced plasticity |
| title_full_unstemmed | Chronic caffeine consumption curbs rTMS-induced plasticity |
| title_short | Chronic caffeine consumption curbs rTMS-induced plasticity |
| title_sort | chronic caffeine consumption curbs rtms induced plasticity |
| topic | plasticity transcranial magnetic stimulation caffeine long-term potentiation d-cycloserine motor evoked potentials |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1137681/full |
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