The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research
Abstract Objective: We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals. Design: Systematic literature review/meta-analysis. Methods:...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X23004473/type/journal_article |
| _version_ | 1797660600512282624 |
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| author | Alexandre R. Marra Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Maria Celidonio Gutfreund Mariana Kim Hsieh Vivian Lin Mohammed Alsuhaibani Shinya Hasegawa Joseph Tholany Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Luiz Vicente Rizzo |
| author_facet | Alexandre R. Marra Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Maria Celidonio Gutfreund Mariana Kim Hsieh Vivian Lin Mohammed Alsuhaibani Shinya Hasegawa Joseph Tholany Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Luiz Vicente Rizzo |
| author_sort | Alexandre R. Marra |
| collection | DOAJ |
| description |
Abstract
Objective:
We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals.
Design:
Systematic literature review/meta-analysis.
Methods:
We searched PubMed, Cumulative Index to Nursing and Allied Health, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 1, 2019, to June 2, 2023, for studies evaluating the COVID-19 vaccine effectiveness (VE) against post-COVID conditions among fully vaccinated individuals who received two doses of COVID-19 vaccine. A post-COVID condition was defined as any symptom that was present four or more weeks after COVID-19 infection. We calculated the pooled diagnostic odds ratio (DOR) (95% confidence interval) for post-COVID conditions between fully vaccinated and unvaccinated individuals. Vaccine effectiveness was estimated as 100% x (1-DOR).
Results:
Thirty-two studies with 775,931 individuals evaluated the effect of vaccination on post-COVID conditions, of which, twenty-four studies were included in the meta-analysis. The pooled DOR for post-COVID conditions among fully vaccinated individuals was 0.680 (95% CI: 0.523–0.885) with an estimated VE of 32.0% (11.5%–47.7%). Vaccine effectiveness was 36.9% (23.1%–48.2%) among those who received two doses of COVID-19 vaccine before COVID-19 infection and 68.7% (64.7%–72.2%) among those who received three doses before COVID-19 infection. The stratified analysis demonstrated no protection against post-COVID conditions among those who received COVID-19 vaccination after COVID-19 infection.
Conclusions:
Receiving a complete COVID-19 vaccination prior to contracting the virus resulted in a significant reduction in post-COVID conditions throughout the study period, including during the Omicron era. Vaccine effectiveness demonstrated an increase when supplementary doses were administered.
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| first_indexed | 2024-03-11T18:33:13Z |
| format | Article |
| id | doaj.art-bba5e99c647d4dffbf0ba6512d863266 |
| institution | Directory Open Access Journal |
| issn | 2732-494X |
| language | English |
| last_indexed | 2024-03-11T18:33:13Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj.art-bba5e99c647d4dffbf0ba6512d8632662023-10-13T09:36:16ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2023-01-01310.1017/ash.2023.447The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest researchAlexandre R. Marra0https://orcid.org/0000-0002-7577-7688Takaaki Kobayashi1https://orcid.org/0000-0003-4751-6859Gustavo Yano Callado2https://orcid.org/0000-0001-6694-6569Isabele Pardo3https://orcid.org/0009-0004-6375-4640Maria Celidonio Gutfreund4Mariana Kim Hsieh5https://orcid.org/0000-0001-8709-5484Vivian Lin6https://orcid.org/0009-0009-2415-5799Mohammed Alsuhaibani7Shinya Hasegawa8https://orcid.org/0000-0001-7167-270XJoseph Tholany9https://orcid.org/0000-0003-4415-4573Eli N. Perencevich10Jorge L. Salinas11Michael B. Edmond12Luiz Vicente Rizzo13Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Center for Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, IA, USADepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USAFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilDepartment of Pediatrics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi ArabiaDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USADepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USADepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA Center for Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, IA, USAStanford University, Stanford, CA, USAWest Virginia University School of Medicine, Morgantown, WV, USAFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Abstract Objective: We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals. Design: Systematic literature review/meta-analysis. Methods: We searched PubMed, Cumulative Index to Nursing and Allied Health, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 1, 2019, to June 2, 2023, for studies evaluating the COVID-19 vaccine effectiveness (VE) against post-COVID conditions among fully vaccinated individuals who received two doses of COVID-19 vaccine. A post-COVID condition was defined as any symptom that was present four or more weeks after COVID-19 infection. We calculated the pooled diagnostic odds ratio (DOR) (95% confidence interval) for post-COVID conditions between fully vaccinated and unvaccinated individuals. Vaccine effectiveness was estimated as 100% x (1-DOR). Results: Thirty-two studies with 775,931 individuals evaluated the effect of vaccination on post-COVID conditions, of which, twenty-four studies were included in the meta-analysis. The pooled DOR for post-COVID conditions among fully vaccinated individuals was 0.680 (95% CI: 0.523–0.885) with an estimated VE of 32.0% (11.5%–47.7%). Vaccine effectiveness was 36.9% (23.1%–48.2%) among those who received two doses of COVID-19 vaccine before COVID-19 infection and 68.7% (64.7%–72.2%) among those who received three doses before COVID-19 infection. The stratified analysis demonstrated no protection against post-COVID conditions among those who received COVID-19 vaccination after COVID-19 infection. Conclusions: Receiving a complete COVID-19 vaccination prior to contracting the virus resulted in a significant reduction in post-COVID conditions throughout the study period, including during the Omicron era. Vaccine effectiveness demonstrated an increase when supplementary doses were administered. https://www.cambridge.org/core/product/identifier/S2732494X23004473/type/journal_article |
| spellingShingle | Alexandre R. Marra Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Maria Celidonio Gutfreund Mariana Kim Hsieh Vivian Lin Mohammed Alsuhaibani Shinya Hasegawa Joseph Tholany Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Luiz Vicente Rizzo The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research Antimicrobial Stewardship & Healthcare Epidemiology |
| title | The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research |
| title_full | The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research |
| title_fullStr | The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research |
| title_full_unstemmed | The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research |
| title_short | The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research |
| title_sort | effectiveness of covid 19 vaccine in the prevention of post covid conditions a systematic literature review and meta analysis of the latest research |
| url | https://www.cambridge.org/core/product/identifier/S2732494X23004473/type/journal_article |
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