Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion
NLRP3 inflammasome is a polyprotein complex with complicated structure and unknown regulatory mechanism. Excessive activation of NLRP3 inflammasome is believed to be related to pathophysiological processes with multiple systemic diseases. Cerebral ischemia is the cerebrovascular disease with the hig...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-01-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191262.pdf |
| _version_ | 1797365809829380096 |
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| author | GUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi |
| author_facet | GUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi |
| author_sort | GUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi |
| collection | DOAJ |
| description | NLRP3 inflammasome is a polyprotein complex with complicated structure and unknown regulatory mechanism. Excessive activation of NLRP3 inflammasome is believed to be related to pathophysiological processes with multiple systemic diseases. Cerebral ischemia is the cerebrovascular disease with the highest incidence. Due to the limited application of thrombolytic therapy, it is particularly important to develop neuroprotective drugs after cerebral ischemia. Identification effective drug targets may provide new approaches in the treatment of cerebral ischemia-reperfusion injury(CIRI). |
| first_indexed | 2024-03-08T16:55:15Z |
| format | Article |
| id | doaj.art-bba9e75109134eeebe0cbf7e97d549ec |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:55:15Z |
| publishDate | 2021-01-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-bba9e75109134eeebe0cbf7e97d549ec2024-01-05T03:04:14ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-01-01411120124Effect of NLRP3 inflammasome on cerebral ischemia-reperfusionGUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi0Medical College of Three Gorges University,Yichang 443002,ChinaNLRP3 inflammasome is a polyprotein complex with complicated structure and unknown regulatory mechanism. Excessive activation of NLRP3 inflammasome is believed to be related to pathophysiological processes with multiple systemic diseases. Cerebral ischemia is the cerebrovascular disease with the highest incidence. Due to the limited application of thrombolytic therapy, it is particularly important to develop neuroprotective drugs after cerebral ischemia. Identification effective drug targets may provide new approaches in the treatment of cerebral ischemia-reperfusion injury(CIRI).http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191262.pdfcerebral ischemia-reperfusion|nlrp3 inflammasome|activation|negative regulation |
| spellingShingle | GUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion Jichu yixue yu linchuang cerebral ischemia-reperfusion|nlrp3 inflammasome|activation|negative regulation |
| title | Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion |
| title_full | Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion |
| title_fullStr | Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion |
| title_full_unstemmed | Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion |
| title_short | Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion |
| title_sort | effect of nlrp3 inflammasome on cerebral ischemia reperfusion |
| topic | cerebral ischemia-reperfusion|nlrp3 inflammasome|activation|negative regulation |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191262.pdf |
| work_keys_str_mv | AT guoyanqinyinbokaizhangjuanhezhi effectofnlrp3inflammasomeoncerebralischemiareperfusion |