First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies.

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies.

<h4>Background</h4>Animal embryotoxicity data, and the scarcity of safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis of prospective...

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Main Authors: Stephanie Dellicour, Esperança Sevene, Rose McGready, Halidou Tinto, Dominic Mosha, Christine Manyando, Stephen Rulisa, Meghna Desai, Peter Ouma, Martina Oneko, Anifa Vala, Maria Rupérez, Eusébio Macete, Clara Menéndez, Seydou Nakanabo-Diallo, Adama Kazienga, Innocent Valéa, Gregory Calip, Orvalho Augusto, Blaise Genton, Eric M Njunju, Kerryn A Moore, Umberto d'Alessandro, Francois Nosten, Feiko Ter Kuile, Andy Stergachis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002290

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