Distinct Effects of Familial Parkinson’s Disease-Associated Mutations on α-Synuclein Phase Separation and Amyloid Aggregation

Distinct Effects of Familial Parkinson’s Disease-Associated Mutations on α-Synuclein Phase Separation and Amyloid Aggregation

The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson’s disease (PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) aggregation, leading to the formation of Lewy bodies and Lewy neurites. Recent studies suggest α-Syn nucleates through liquid–liq...

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Bibliographic Details
Main Authors: Bingkuan Xu, Fengshuo Fan, Yunpeng Liu, Yinghui Liu, Lin Zhou, Haijia Yu
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
α-synuclein
mutation
phase transition
amyloid aggregation
liquid–liquid phase separation (LLPS)
Parkinson’s disease (PD)
Online Access:https://www.mdpi.com/2218-273X/13/5/726

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