Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients
Background: Coronavirus infectious disease 2019 (COVID-19) is a significant public health problem worldwide. COVID-19 increases the risk of non-pulmonary complications such as acute myocardial injury, renal failure, thromboembolic events, and multi-organic damage. Several studies have documented inc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/14/3950 |
| _version_ | 1797406058720788480 |
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| author | Arturo Orea-Tejada Carlos Sánchez-Moreno Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Dulce González-Islas Yazmín Debray-García Manolo Sibael Ortega-Romero Candace Keirns-Davis Laura Cornejo-Cornejo Jorge Aguilar-Meza |
| author_facet | Arturo Orea-Tejada Carlos Sánchez-Moreno Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Dulce González-Islas Yazmín Debray-García Manolo Sibael Ortega-Romero Candace Keirns-Davis Laura Cornejo-Cornejo Jorge Aguilar-Meza |
| author_sort | Arturo Orea-Tejada |
| collection | DOAJ |
| description | Background: Coronavirus infectious disease 2019 (COVID-19) is a significant public health problem worldwide. COVID-19 increases the risk of non-pulmonary complications such as acute myocardial injury, renal failure, thromboembolic events, and multi-organic damage. Several studies have documented increased inflammation molecules, endothelial dysfunction biomarkers, and dysregulation of coagulation factors in COVID-19 patients. In addition, endothelium dysfunction is exacerbated by the oxidative stress (OxS) promoted by endocrine and cardiovascular molecules. Our objective was to evaluate whether endothelial and OxS biomarkers were associated with mortality in hospitalized COVID-19 patients. Methods: A prospective cohort study was performed. Patients ≥18 years old with confirmed COVID-19 that required hospitalization were included in a prospective cohort study. Endothelium and oxidative stress biomarkers were collected between 3 and 5 days after admission. Results: A total of 165 patients were evaluated; 56 patients succumbed. The median follow-up was 71 days [23–129]. Regarding endothelial dysfunction and OxS biomarkers, patients who did not survive had higher levels of nitrates (0.4564 [0.1817–0.6761] vs. 0.2817 [0.0517–0.5], <i>p</i> = 0.014), total nitrates (0.0507 [−0.0342–0.1809] vs. −0.0041 [−0.0887–0.0909], <i>p</i> = 0.016), sE-Selectin (1.095 [0.86–1.495] vs. 0.94 [0.71–1.19], <i>p</i> = 0.004), and malondialdehyde (MDA) (0.50 [0.26–0.72] vs. 0.36 [0.23–0.52], <i>p</i> = 0.010) compared to patients who survived. Endothelial and OxS biomarkers independently associated with mortality were sE-selectin (HR:2.54, CI95%; from 1.11 to 5.81, <i>p</i> = 0.027), nitrates (HR:4.92, CI95%; from 1.23 to 19.63, <i>p</i> = 0.024), and MDA (HR: 3.05, CI95%; from 1.14 to 8.15, <i>p</i> = 0.025). Conclusions: Endothelial dysfunction (sE-selectin and nitrates) and OxS (MDA) are independent indicators of a worse prognosis in COVID-19 patients requiring hospitalization. |
| first_indexed | 2024-03-09T03:19:12Z |
| format | Article |
| id | doaj.art-bbad13b1a9394f5181fb868362fb7040 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:19:12Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bbad13b1a9394f5181fb868362fb70402023-12-03T15:12:25ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011114395010.3390/jcm11143950Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 PatientsArturo Orea-Tejada0Carlos Sánchez-Moreno1Octavio Gamaliel Aztatzi-Aguilar2Martha Patricia Sierra-Vargas3Dulce González-Islas4Yazmín Debray-García5Manolo Sibael Ortega-Romero6Candace Keirns-Davis7Laura Cornejo-Cornejo8Jorge Aguilar-Meza9Heart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHeart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoDepartment of Toxicology and Environmental Medicine Research, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoSubdivision of Clinical Research, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHeart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoDepartment of Toxicology and Environmental Medicine Research, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoDepartment of Toxicology and Environmental Medicine Research, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHeart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHeart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHeart Failure and Respiratory Distress Clinic, Cardiology Service, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoBackground: Coronavirus infectious disease 2019 (COVID-19) is a significant public health problem worldwide. COVID-19 increases the risk of non-pulmonary complications such as acute myocardial injury, renal failure, thromboembolic events, and multi-organic damage. Several studies have documented increased inflammation molecules, endothelial dysfunction biomarkers, and dysregulation of coagulation factors in COVID-19 patients. In addition, endothelium dysfunction is exacerbated by the oxidative stress (OxS) promoted by endocrine and cardiovascular molecules. Our objective was to evaluate whether endothelial and OxS biomarkers were associated with mortality in hospitalized COVID-19 patients. Methods: A prospective cohort study was performed. Patients ≥18 years old with confirmed COVID-19 that required hospitalization were included in a prospective cohort study. Endothelium and oxidative stress biomarkers were collected between 3 and 5 days after admission. Results: A total of 165 patients were evaluated; 56 patients succumbed. The median follow-up was 71 days [23–129]. Regarding endothelial dysfunction and OxS biomarkers, patients who did not survive had higher levels of nitrates (0.4564 [0.1817–0.6761] vs. 0.2817 [0.0517–0.5], <i>p</i> = 0.014), total nitrates (0.0507 [−0.0342–0.1809] vs. −0.0041 [−0.0887–0.0909], <i>p</i> = 0.016), sE-Selectin (1.095 [0.86–1.495] vs. 0.94 [0.71–1.19], <i>p</i> = 0.004), and malondialdehyde (MDA) (0.50 [0.26–0.72] vs. 0.36 [0.23–0.52], <i>p</i> = 0.010) compared to patients who survived. Endothelial and OxS biomarkers independently associated with mortality were sE-selectin (HR:2.54, CI95%; from 1.11 to 5.81, <i>p</i> = 0.027), nitrates (HR:4.92, CI95%; from 1.23 to 19.63, <i>p</i> = 0.024), and MDA (HR: 3.05, CI95%; from 1.14 to 8.15, <i>p</i> = 0.025). Conclusions: Endothelial dysfunction (sE-selectin and nitrates) and OxS (MDA) are independent indicators of a worse prognosis in COVID-19 patients requiring hospitalization.https://www.mdpi.com/2077-0383/11/14/3950COVID-19oxidative stressendothelial dysfunctionmortality |
| spellingShingle | Arturo Orea-Tejada Carlos Sánchez-Moreno Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Dulce González-Islas Yazmín Debray-García Manolo Sibael Ortega-Romero Candace Keirns-Davis Laura Cornejo-Cornejo Jorge Aguilar-Meza Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients Journal of Clinical Medicine COVID-19 oxidative stress endothelial dysfunction mortality |
| title | Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients |
| title_full | Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients |
| title_fullStr | Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients |
| title_full_unstemmed | Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients |
| title_short | Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients |
| title_sort | plasma endothelial and oxidative stress biomarkers associated with late mortality in hospitalized covid 19 patients |
| topic | COVID-19 oxidative stress endothelial dysfunction mortality |
| url | https://www.mdpi.com/2077-0383/11/14/3950 |
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