Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study
The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (∆CIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Da...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2023-02-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100614&lng=en&tlng=en |
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| author | W.R. Tebar I.S. Santos V. Meneghini M.S. Bittencourt P.A. Lotufo I.M. Bensenor |
| author_facet | W.R. Tebar I.S. Santos V. Meneghini M.S. Bittencourt P.A. Lotufo I.M. Bensenor |
| author_sort | W.R. Tebar |
| collection | DOAJ |
| description | The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (∆CIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Data from 7564 participants were analyzed (median age of 50.0 [44.0-57.0] years, 56.9% women). CIMT was assessed by ultrasound and ∆CIMT was calculated by subtracting baseline values from follow-up values. Psoriasis participants were identified by self-reported medical diagnosis (n=143) and compared with matched participants without disease (n=572) and with the entire sample without psoriasis (n=7421). Baseline CIMT explained the 8-year CIMT increase only in 36.9% among psoriasis participants and in ∼43.0% in participants without disease. CIMT was associated with age (β=0.002, P=0.002) and hypertension (β=0.029, P=0.034) in psoriasis participants. Among participants without psoriasis, CIMT was associated with age, male sex, low educational attainment, past smoking, obesity, diabetes, hypertension, and dyslipidemia (P<0.05). There was an inverse association of CIMT with private health insurance (β=-0.004, P=0.042) and White ethnicity (β=-0.006, P=0.004) in the entire sample without psoriasis but not in matched participants. Psoriasis participants showed an inverse association between ∆CIMT and diabetes (β=-0.214, P=0.011), while the entire sample without psoriasis showed an inverse association between ∆CIMT and age (β=-0.005, P<0.001), past smoking (β=-0.048, P=0.009), and hypertension (β=-0.048, P=0.009). In conclusion, psoriasis was not associated with CIMT after an 8-year follow-up. The inverse association of ∆CIMT with diabetes in psoriasis participants needs further clarification. |
| first_indexed | 2024-04-10T06:56:28Z |
| format | Article |
| id | doaj.art-bbaebd4efa2d45828fbf700b1807cc1c |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-10T06:56:28Z |
| publishDate | 2023-02-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-bbaebd4efa2d45828fbf700b1807cc1c2023-02-28T07:32:50ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2023-02-015610.1590/1414-431x2023e12609Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort studyW.R. Tebarhttps://orcid.org/0000-0002-6192-4667I.S. Santoshttps://orcid.org/0000-0003-3212-8466V. Meneghinihttps://orcid.org/0000-0002-2787-6841M.S. Bittencourthttps://orcid.org/0000-0002-3711-1754P.A. Lotufohttps://orcid.org/0000-0002-4856-8450I.M. Bensenorhttps://orcid.org/0000-0002-6723-5678The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (∆CIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Data from 7564 participants were analyzed (median age of 50.0 [44.0-57.0] years, 56.9% women). CIMT was assessed by ultrasound and ∆CIMT was calculated by subtracting baseline values from follow-up values. Psoriasis participants were identified by self-reported medical diagnosis (n=143) and compared with matched participants without disease (n=572) and with the entire sample without psoriasis (n=7421). Baseline CIMT explained the 8-year CIMT increase only in 36.9% among psoriasis participants and in ∼43.0% in participants without disease. CIMT was associated with age (β=0.002, P=0.002) and hypertension (β=0.029, P=0.034) in psoriasis participants. Among participants without psoriasis, CIMT was associated with age, male sex, low educational attainment, past smoking, obesity, diabetes, hypertension, and dyslipidemia (P<0.05). There was an inverse association of CIMT with private health insurance (β=-0.004, P=0.042) and White ethnicity (β=-0.006, P=0.004) in the entire sample without psoriasis but not in matched participants. Psoriasis participants showed an inverse association between ∆CIMT and diabetes (β=-0.214, P=0.011), while the entire sample without psoriasis showed an inverse association between ∆CIMT and age (β=-0.005, P<0.001), past smoking (β=-0.048, P=0.009), and hypertension (β=-0.048, P=0.009). In conclusion, psoriasis was not associated with CIMT after an 8-year follow-up. The inverse association of ∆CIMT with diabetes in psoriasis participants needs further clarification.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100614&lng=en&tlng=enCardiovascular riskCarotid intima-media thicknessInflammatory diseasePsoriasisSubclinical arterial disease |
| spellingShingle | W.R. Tebar I.S. Santos V. Meneghini M.S. Bittencourt P.A. Lotufo I.M. Bensenor Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study Brazilian Journal of Medical and Biological Research Cardiovascular risk Carotid intima-media thickness Inflammatory disease Psoriasis Subclinical arterial disease |
| title | Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study |
| title_full | Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study |
| title_fullStr | Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study |
| title_full_unstemmed | Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study |
| title_short | Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study |
| title_sort | eight year change in carotid intima media thickness and associated risk factors in adults with and without psoriasis the elsa brasil cohort study |
| topic | Cardiovascular risk Carotid intima-media thickness Inflammatory disease Psoriasis Subclinical arterial disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100614&lng=en&tlng=en |
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