Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders
This review investigates the multifaceted role of the p66Shc adaptor protein and the gut microbiota in regulating mitochondrial function and oxidative stress, and their collective impact on the pathogenesis of chronic diseases. The study delves into the molecular mechanisms by which p66Shc influence...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/7/3656 |
| _version_ | 1797212519440318464 |
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| author | Ana Clara da C. Pinaffi-Langley Elizabeth Melia Franklin A. Hays |
| author_facet | Ana Clara da C. Pinaffi-Langley Elizabeth Melia Franklin A. Hays |
| author_sort | Ana Clara da C. Pinaffi-Langley |
| collection | DOAJ |
| description | This review investigates the multifaceted role of the p66Shc adaptor protein and the gut microbiota in regulating mitochondrial function and oxidative stress, and their collective impact on the pathogenesis of chronic diseases. The study delves into the molecular mechanisms by which p66Shc influences cellular stress responses through Rac1 activation, Forkhead-type transcription factors inactivation, and mitochondria-mediated apoptosis, alongside modulatory effects of gut microbiota-derived metabolites and endotoxins. Employing an integrative approach, the review synthesizes findings from a broad array of studies, including molecular biology techniques and analyses of microbial metabolites’ impacts on host cellular pathways. The results underscore a complex interplay between microbial metabolites, p66Shc activation, and mitochondrial dysfunction, highlighting the significance of the gut microbiome in influencing disease outcomes through oxidative stress pathways. Conclusively, the review posits that targeting the gut microbiota-p66Shc–mitochondrial axis could offer novel therapeutic strategies for mitigating the development and progression of metabolic diseases. This underscores the potential of dietary interventions and microbiota modulation in managing oxidative stress and inflammation, pivotal factors in chronic disease etiology. |
| first_indexed | 2024-04-24T10:43:40Z |
| format | Article |
| id | doaj.art-bbafcec32a224b858acc61c78f0b1734 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T10:43:40Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bbafcec32a224b858acc61c78f0b17342024-04-12T13:19:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01257365610.3390/ijms25073656Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic DisordersAna Clara da C. Pinaffi-Langley0Elizabeth Melia1Franklin A. Hays2Department of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences, Oklahoma City, OK 73117, USADepartment of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences, Oklahoma City, OK 73117, USADepartment of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences, Oklahoma City, OK 73117, USAThis review investigates the multifaceted role of the p66Shc adaptor protein and the gut microbiota in regulating mitochondrial function and oxidative stress, and their collective impact on the pathogenesis of chronic diseases. The study delves into the molecular mechanisms by which p66Shc influences cellular stress responses through Rac1 activation, Forkhead-type transcription factors inactivation, and mitochondria-mediated apoptosis, alongside modulatory effects of gut microbiota-derived metabolites and endotoxins. Employing an integrative approach, the review synthesizes findings from a broad array of studies, including molecular biology techniques and analyses of microbial metabolites’ impacts on host cellular pathways. The results underscore a complex interplay between microbial metabolites, p66Shc activation, and mitochondrial dysfunction, highlighting the significance of the gut microbiome in influencing disease outcomes through oxidative stress pathways. Conclusively, the review posits that targeting the gut microbiota-p66Shc–mitochondrial axis could offer novel therapeutic strategies for mitigating the development and progression of metabolic diseases. This underscores the potential of dietary interventions and microbiota modulation in managing oxidative stress and inflammation, pivotal factors in chronic disease etiology.https://www.mdpi.com/1422-0067/25/7/3656p66Shcadaptor proteinoxidative stressgut microbiotainflammationmitochondrial dysfunction |
| spellingShingle | Ana Clara da C. Pinaffi-Langley Elizabeth Melia Franklin A. Hays Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders International Journal of Molecular Sciences p66Shc adaptor protein oxidative stress gut microbiota inflammation mitochondrial dysfunction |
| title | Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders |
| title_full | Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders |
| title_fullStr | Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders |
| title_full_unstemmed | Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders |
| title_short | Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders |
| title_sort | exploring the gut mitochondrial axis p66shc adapter protein and its implications for metabolic disorders |
| topic | p66Shc adaptor protein oxidative stress gut microbiota inflammation mitochondrial dysfunction |
| url | https://www.mdpi.com/1422-0067/25/7/3656 |
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