Identification of rare thalassemia variants using third-generation sequencing

Identification of rare thalassemia variants using third-generation sequencing

Routine PCR, Sanger sequencing, and specially designed GAP-PCR are often used in the genetic analysis of thalassemia, but all these methods have limitations. In this study, we evaluated a new third-generation sequencing-based approach termed comprehensive analysis of thalassemia alleles (CATSA) in s...

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Bibliographic Details
Main Authors: Qin Liu, Qianting Chen, Zonglei Zhang, Shiyi Peng, Jing Liu, Jialun Pang, Zhengjun Jia, Hui Xi, Jiaqi Li, Libao Chen, Yinyin Liu, Ying Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genetics
Subjects:
thalassemia
third-generation sequencing
genetic analysis
hemoglobin
variant
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1076035/full

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