Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection

Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection

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During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in the context of chronic infections and cancer. Altho...

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Bibliographic Details
Main Authors: Lauren K. Quezada, Wenhao Jin, Yi Chia Liu, Eleanor S. Kim, Zhaoren He, Cynthia S. Indralingam, Tiffani Tysl, Lara Labarta-Bajo, Ellen J. Wehrens, Yeara Jo, Katelynn R. Kazane, Christopher Hattori, Elina I. Zuniga, Gene W. Yeo, John T. Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886247/?tool=EBI

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