Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy
Abstract Introduction Ultrasound‐guided fine needle aspiration biopsy (FNAB) is currently widely used for the initial screening of patients with thyroid nodules enabling prevention of unnecessary surgery. The purpose of this study was to retrospectively analyse the diagnostic accuracy of thyroid FNA...
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.373 |
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| author | Aziz Aliyev Irada Aliyeva Francesco Giammarile Narmin Talibova Gunay Aliyeva Fuad Novruzov |
| author_facet | Aziz Aliyev Irada Aliyeva Francesco Giammarile Narmin Talibova Gunay Aliyeva Fuad Novruzov |
| author_sort | Aziz Aliyev |
| collection | DOAJ |
| description | Abstract Introduction Ultrasound‐guided fine needle aspiration biopsy (FNAB) is currently widely used for the initial screening of patients with thyroid nodules enabling prevention of unnecessary surgery. The purpose of this study was to retrospectively analyse the diagnostic accuracy of thyroid FNAB compared with postoperative histopathology of a large cohort from Azerbaijan. Methods We evaluated the FNAB results of 738 patients who underwent thyroid surgery at the National Centre of Oncology in Azerbaijan. The measures of diagnostic accuracy were calculated for the ultrasound‐guided preoperative FNAB results (based on the six diagnostic categories of the Bethesda classification) compared with postoperative histopathologic results (benign or malignant) for correspondent areas. Results Considering both DC V and DC VI categories (387 cases) as ‘cytologic‐positive’ and DC II category (72 cases) as ‘cytologic‐negative’, we found 14 false‐positive and 10 false‐negative results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were 97.4%, 86.1%, 96.4%, 81.6% and 94.8%, respectively. Conversely, when considering only the DC VI category as ‘cytologic‐positive’, the sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNA were 93.2%, 100%, 100%, 81.6% and 97.1%, respectively. Conclusions The results of our cohort demonstrated high levels of diagnostic accuracy, supporting FNAB's role as a reliable diagnostic tool in the preoperative evaluation of thyroid nodules. The sensitivity, specificity, NPV, PPV and accuracy of thyroid FNAB in our institution were comparable with those of other institutions. |
| first_indexed | 2024-04-11T06:48:19Z |
| format | Article |
| id | doaj.art-bbbb347f46ee4736b5a70bfc4eec3a44 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-04-11T06:48:19Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-bbbb347f46ee4736b5a70bfc4eec3a442022-12-22T04:39:18ZengWileyEndocrinology, Diabetes & Metabolism2398-92382022-11-0156n/an/a10.1002/edm2.373Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancyAziz Aliyev0Irada Aliyeva1Francesco Giammarile2Narmin Talibova3Gunay Aliyeva4Fuad Novruzov5Department of Head and Neck Surgery, Azerbaijan National Centre of Oncology Baku AzerbaijanDepartment of Internal Medicine, Azerbaijan Medical University Baku AzerbaijanInternational Atomic Energy Agency Vienna AustriaDepartment of Medical Oncology, Azerbaijan National Centre of Oncology Baku AzerbaijanDepartment of Nuclear Medicine, Azerbaijan National Centre of Oncology Baku AzerbaijanDepartment of Nuclear Medicine, Azerbaijan National Centre of Oncology Baku AzerbaijanAbstract Introduction Ultrasound‐guided fine needle aspiration biopsy (FNAB) is currently widely used for the initial screening of patients with thyroid nodules enabling prevention of unnecessary surgery. The purpose of this study was to retrospectively analyse the diagnostic accuracy of thyroid FNAB compared with postoperative histopathology of a large cohort from Azerbaijan. Methods We evaluated the FNAB results of 738 patients who underwent thyroid surgery at the National Centre of Oncology in Azerbaijan. The measures of diagnostic accuracy were calculated for the ultrasound‐guided preoperative FNAB results (based on the six diagnostic categories of the Bethesda classification) compared with postoperative histopathologic results (benign or malignant) for correspondent areas. Results Considering both DC V and DC VI categories (387 cases) as ‘cytologic‐positive’ and DC II category (72 cases) as ‘cytologic‐negative’, we found 14 false‐positive and 10 false‐negative results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were 97.4%, 86.1%, 96.4%, 81.6% and 94.8%, respectively. Conversely, when considering only the DC VI category as ‘cytologic‐positive’, the sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNA were 93.2%, 100%, 100%, 81.6% and 97.1%, respectively. Conclusions The results of our cohort demonstrated high levels of diagnostic accuracy, supporting FNAB's role as a reliable diagnostic tool in the preoperative evaluation of thyroid nodules. The sensitivity, specificity, NPV, PPV and accuracy of thyroid FNAB in our institution were comparable with those of other institutions.https://doi.org/10.1002/edm2.373Bethesda classificationfine needle aspiration biopsythyroid nodules |
| spellingShingle | Aziz Aliyev Irada Aliyeva Francesco Giammarile Narmin Talibova Gunay Aliyeva Fuad Novruzov Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy Endocrinology, Diabetes & Metabolism Bethesda classification fine needle aspiration biopsy thyroid nodules |
| title | Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| title_full | Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| title_fullStr | Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| title_full_unstemmed | Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| title_short | Diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| title_sort | diagnostic accuracy of fine needle aspiration biopsy versus postoperative histopathology for diagnosing thyroid malignancy |
| topic | Bethesda classification fine needle aspiration biopsy thyroid nodules |
| url | https://doi.org/10.1002/edm2.373 |
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