Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies
New symmetrically para-substituted tetraphenylporphyrin Tl(III) salicylate complexes, having the general formula SA/5-SSATl(III)t(4-Y)PP (Y=-H, -CH3, -OCH3); SA=salicylates and 5-SSA=5-sulfosalicylates, were synthesized and characterized by elemental analysis, optical absorption/emission studies, in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2016-04-01
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| Series: | Main Group Metal Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mgmc-2015-0027 |
| _version_ | 1819117606959841280 |
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| author | Bajju Gauri D. Katoch Sapna Devi Gita Kundan Sujata Ashu Bhagat Madhullika |
| author_facet | Bajju Gauri D. Katoch Sapna Devi Gita Kundan Sujata Ashu Bhagat Madhullika |
| author_sort | Bajju Gauri D. |
| collection | DOAJ |
| description | New symmetrically para-substituted tetraphenylporphyrin Tl(III) salicylate complexes, having the general formula SA/5-SSATl(III)t(4-Y)PP (Y=-H, -CH3, -OCH3); SA=salicylates and 5-SSA=5-sulfosalicylates, were synthesized and characterized by elemental analysis, optical absorption/emission studies, infrared spectrum, NMR studies (1H, 205Tl), thermal analysis and mass spectra; the complexes are in good consistency with experimental results. All the newly synthesized complexes exhibited good optical property, and thermogravimetric analysis (TGA) results showed their excellent thermal stability (>400°C). Macrocyclic complexes of Tl(III) ligate to axial ligand to form six-coordinate complex, the nature of which influences the photophysical properties of the former depending upon the spin-orbital coupling character of the axial ligand. A square-based pyramidal structure has been proposed on the basis of these studies. In addition, some of the synthesized complexes of thallium porphyrins were also screened for anti-bacterial activity. Cytotoxic activity of 5-SSATl(III)t (4-OCH3)PP evaluated against four human cancer cell lines exhibited strong (up to 90%) growth inhibition. |
| first_indexed | 2024-12-22T05:35:40Z |
| format | Article |
| id | doaj.art-bbbcb8f06b854094a34b8c0cb84a6c2a |
| institution | Directory Open Access Journal |
| issn | 0792-1241 2191-0219 |
| language | English |
| last_indexed | 2024-12-22T05:35:40Z |
| publishDate | 2016-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Main Group Metal Chemistry |
| spelling | doaj.art-bbbcb8f06b854094a34b8c0cb84a6c2a2022-12-21T18:37:19ZengDe GruyterMain Group Metal Chemistry0792-12412191-02192016-04-01391-2192910.1515/mgmc-2015-0027Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studiesBajju Gauri D.0Katoch Sapna1Devi Gita2Kundan Sujata3Ashu4Bhagat Madhullika5Department of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaDepartment of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaDepartment of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaDepartment of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaDepartment of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaSchool of Biotechnology, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu 180 006, IndiaNew symmetrically para-substituted tetraphenylporphyrin Tl(III) salicylate complexes, having the general formula SA/5-SSATl(III)t(4-Y)PP (Y=-H, -CH3, -OCH3); SA=salicylates and 5-SSA=5-sulfosalicylates, were synthesized and characterized by elemental analysis, optical absorption/emission studies, infrared spectrum, NMR studies (1H, 205Tl), thermal analysis and mass spectra; the complexes are in good consistency with experimental results. All the newly synthesized complexes exhibited good optical property, and thermogravimetric analysis (TGA) results showed their excellent thermal stability (>400°C). Macrocyclic complexes of Tl(III) ligate to axial ligand to form six-coordinate complex, the nature of which influences the photophysical properties of the former depending upon the spin-orbital coupling character of the axial ligand. A square-based pyramidal structure has been proposed on the basis of these studies. In addition, some of the synthesized complexes of thallium porphyrins were also screened for anti-bacterial activity. Cytotoxic activity of 5-SSATl(III)t (4-OCH3)PP evaluated against four human cancer cell lines exhibited strong (up to 90%) growth inhibition.https://doi.org/10.1515/mgmc-2015-0027antibacterial activitycytotoxic activitymacrocyclic complexessalicylatestetraphenylporphyrins |
| spellingShingle | Bajju Gauri D. Katoch Sapna Devi Gita Kundan Sujata Ashu Bhagat Madhullika Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies Main Group Metal Chemistry antibacterial activity cytotoxic activity macrocyclic complexes salicylates tetraphenylporphyrins |
| title | Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies |
| title_full | Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies |
| title_fullStr | Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies |
| title_full_unstemmed | Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies |
| title_short | Synthesis and characterization of some new thallium(III) macrocyclic complexes and their biological studies |
| title_sort | synthesis and characterization of some new thallium iii macrocyclic complexes and their biological studies |
| topic | antibacterial activity cytotoxic activity macrocyclic complexes salicylates tetraphenylporphyrins |
| url | https://doi.org/10.1515/mgmc-2015-0027 |
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