Facial rash in a newborn
A female newborn, born at 38 weeks from an uncomplicated pregnancy in a healthy 36-years-old mother, presented at birth with desquamative erythematous plaques with irregular borders, distributed bilaterally in the orbital, nasal and malar regions. Although there was no history of maternal autoimmune...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2021-12-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://jpnim.com/index.php/jpnim/article/view/1089 |
| _version_ | 1819103563860672512 |
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| author | Sílvia Mota Carla Sá Nicole Silva Filipa Almeida Ana Paula Vieira Almerinda Pereira |
| author_facet | Sílvia Mota Carla Sá Nicole Silva Filipa Almeida Ana Paula Vieira Almerinda Pereira |
| author_sort | Sílvia Mota |
| collection | DOAJ |
| description | A female newborn, born at 38 weeks from an uncomplicated pregnancy in a healthy 36-years-old mother, presented at birth with desquamative erythematous plaques with irregular borders, distributed bilaterally in the orbital, nasal and malar regions. Although there was no history of maternal autoimmune disease, neonatal lupus (NL) was suspected. Maternal and newborn screenings were positive for Sjögren syndrome type A antigen (anti-Ro/SSA) antibodies. No other alterations of NL were found in the newborn. Rheumatologic consultation on the mother showed no other alterations besides the antibodies. The newborn was discharged on day 3 of life without treatment and recommendations to avoid sun exposure. Outpatient follow-up was ensured in neonatology, dermatology and pediatric cardiology. The rash resolved during the first year of life, leaving slight local skin atrophy.
NL is a rare transferred autoimmune disease with an incidence estimated as 1:20,000 live births. It occurs due to placental transfer of maternal autoantibodies. The major manifestations are cardiac and cutaneous, but hepatic, hematologic or neurologic findings may also be present. The rash usually affects the face and scalp and may be present at delivery but more often develops later, after exposure to ultraviolet light. It usually resolves within the first year of life without sequelae. NL is the leading cause of congenital heart block, but if it is not present at birth it rarely develops. Some mothers do not have a known autoimmune disease at the time of birth but may develop it later in life. Despite NL being a passively acquired autoimmune disease, the child is at increased risk of rheumatologic disease in childhood or adolescence. |
| first_indexed | 2024-12-22T01:52:27Z |
| format | Article |
| id | doaj.art-bbbd086de9cf4afe9ab24abfe0660686 |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-22T01:52:27Z |
| publishDate | 2021-12-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-bbbd086de9cf4afe9ab24abfe06606862022-12-21T18:42:53ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922021-12-01111e110127e11012710.7363/1101271108Facial rash in a newbornSílvia Mota0https://orcid.org/0000-0002-4352-503XCarla Sá1Nicole Silva2Filipa Almeida3Ana Paula Vieira4Almerinda Pereira5Pediatric Service, Hospital de Braga, Braga, PortugalNeonatal Special Care Unit, Hospital de Braga, Braga, PortugalNeonatal Special Care Unit, Hospital de Braga, Braga, PortugalDermatology Service, Hospital de Braga, Braga, PortugalDermatology Service, Hospital de Braga, Braga, PortugalPediatric Service, Hospital de Braga, Braga, Portugal; Neonatal Special Care Unit, Hospital de Braga, Braga, PortugalA female newborn, born at 38 weeks from an uncomplicated pregnancy in a healthy 36-years-old mother, presented at birth with desquamative erythematous plaques with irregular borders, distributed bilaterally in the orbital, nasal and malar regions. Although there was no history of maternal autoimmune disease, neonatal lupus (NL) was suspected. Maternal and newborn screenings were positive for Sjögren syndrome type A antigen (anti-Ro/SSA) antibodies. No other alterations of NL were found in the newborn. Rheumatologic consultation on the mother showed no other alterations besides the antibodies. The newborn was discharged on day 3 of life without treatment and recommendations to avoid sun exposure. Outpatient follow-up was ensured in neonatology, dermatology and pediatric cardiology. The rash resolved during the first year of life, leaving slight local skin atrophy. NL is a rare transferred autoimmune disease with an incidence estimated as 1:20,000 live births. It occurs due to placental transfer of maternal autoantibodies. The major manifestations are cardiac and cutaneous, but hepatic, hematologic or neurologic findings may also be present. The rash usually affects the face and scalp and may be present at delivery but more often develops later, after exposure to ultraviolet light. It usually resolves within the first year of life without sequelae. NL is the leading cause of congenital heart block, but if it is not present at birth it rarely develops. Some mothers do not have a known autoimmune disease at the time of birth but may develop it later in life. Despite NL being a passively acquired autoimmune disease, the child is at increased risk of rheumatologic disease in childhood or adolescence.https://jpnim.com/index.php/jpnim/article/view/1089neonatal lupusneonatal autoimmune diseasesjögren syndrome type a antigen antibodiescongenital heart blockfacial rashskin lesions |
| spellingShingle | Sílvia Mota Carla Sá Nicole Silva Filipa Almeida Ana Paula Vieira Almerinda Pereira Facial rash in a newborn Journal of Pediatric and Neonatal Individualized Medicine neonatal lupus neonatal autoimmune disease sjögren syndrome type a antigen antibodies congenital heart block facial rash skin lesions |
| title | Facial rash in a newborn |
| title_full | Facial rash in a newborn |
| title_fullStr | Facial rash in a newborn |
| title_full_unstemmed | Facial rash in a newborn |
| title_short | Facial rash in a newborn |
| title_sort | facial rash in a newborn |
| topic | neonatal lupus neonatal autoimmune disease sjögren syndrome type a antigen antibodies congenital heart block facial rash skin lesions |
| url | https://jpnim.com/index.php/jpnim/article/view/1089 |
| work_keys_str_mv | AT silviamota facialrashinanewborn AT carlasa facialrashinanewborn AT nicolesilva facialrashinanewborn AT filipaalmeida facialrashinanewborn AT anapaulavieira facialrashinanewborn AT almerindapereira facialrashinanewborn |