Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review
<i>Introduction</i>: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. <i>Case presentat...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/824 |
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| author | Sorin Dema Fulger Lazar Robert Barna Amadeus Dobrescu Alis Liliana Carmen Dema Oana Popa Ioana Ionita Sorina Maria Taban |
| author_facet | Sorin Dema Fulger Lazar Robert Barna Amadeus Dobrescu Alis Liliana Carmen Dema Oana Popa Ioana Ionita Sorina Maria Taban |
| author_sort | Sorin Dema |
| collection | DOAJ |
| description | <i>Introduction</i>: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. <i>Case presentation</i>: We present the case of a female patient diagnosed with gallstones for which surgery was decided. Intraoperatively, a malignant tumor of extrahepatic bile ducts was suspected. A frozen section examination raised the suspicion of a mesenchymal tumor or an inflammatory pseudotumor. The histological evaluation of the permanent sections, supplemented with an immunohistochemical investigation (IHC), was the one that established the diagnosis of SEHT, based on the presence of areas of sclerosis, atypical CD31+ megakaryocytes, myeloid and erythroid elements. <i>Conclusions</i>: The authors present the difficulties of a morphological diagnosis on the frozen section and on permanent sections in the absence of relevant clinical information and make a review of the literature data dedicated to the subject. |
| first_indexed | 2024-03-10T08:37:25Z |
| format | Article |
| id | doaj.art-bbbe2009a9fd441ca8d96304abcb4bbd |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:37:25Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-bbbe2009a9fd441ca8d96304abcb4bbd2023-11-22T08:36:40ZengMDPI AGMedicina1010-660X1648-91442021-08-0157882410.3390/medicina57080824Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature ReviewSorin Dema0Fulger Lazar1Robert Barna2Amadeus Dobrescu3Alis Liliana Carmen Dema4Oana Popa5Ioana Ionita6Sorina Maria Taban7Radiotherapy Service, Emergency Clinical City Hospital, 300079 Timisoara, RomaniaResearching Future Surgery 2 Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaAnapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaResearching Future Surgery 2 Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaAnapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaAnapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaMultidisciplinary Research Center for Malignant Hematological Diseases, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, RomaniaAnapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania<i>Introduction</i>: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. <i>Case presentation</i>: We present the case of a female patient diagnosed with gallstones for which surgery was decided. Intraoperatively, a malignant tumor of extrahepatic bile ducts was suspected. A frozen section examination raised the suspicion of a mesenchymal tumor or an inflammatory pseudotumor. The histological evaluation of the permanent sections, supplemented with an immunohistochemical investigation (IHC), was the one that established the diagnosis of SEHT, based on the presence of areas of sclerosis, atypical CD31+ megakaryocytes, myeloid and erythroid elements. <i>Conclusions</i>: The authors present the difficulties of a morphological diagnosis on the frozen section and on permanent sections in the absence of relevant clinical information and make a review of the literature data dedicated to the subject.https://www.mdpi.com/1648-9144/57/8/824sclerosing extramedullary hematopoietic tumorchronic myeloproliferative disorderextrahepatic bile ductsimmunohistochemistry |
| spellingShingle | Sorin Dema Fulger Lazar Robert Barna Amadeus Dobrescu Alis Liliana Carmen Dema Oana Popa Ioana Ionita Sorina Maria Taban Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review Medicina sclerosing extramedullary hematopoietic tumor chronic myeloproliferative disorder extrahepatic bile ducts immunohistochemistry |
| title | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
| title_full | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
| title_fullStr | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
| title_full_unstemmed | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
| title_short | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
| title_sort | sclerosing extramedullary hematopoietic tumor seht mimicking a malignant bile duct tumor case report and literature review |
| topic | sclerosing extramedullary hematopoietic tumor chronic myeloproliferative disorder extrahepatic bile ducts immunohistochemistry |
| url | https://www.mdpi.com/1648-9144/57/8/824 |
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