An Effective Modification Strategy to Build Multifunctional Peptides Based on a Trypsin Inhibitory Peptide of the Kunitz Family

An Effective Modification Strategy to Build Multifunctional Peptides Based on a Trypsin Inhibitory Peptide of the Kunitz Family

Peptides with antimicrobial activity or protease inhibitory activity are potential candidates to supplement traditional antibiotics or cancer chemotherapies. However, the potential of many peptides are limited by drawbacks such as cytotoxicity or susceptibility to hydrolysis. Therefore, strategies t...

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Bibliographic Details
Main Authors: Ying Wang, Daning Shi, Wanchen Zou, Yangyang Jiang, Tao Wang, Xiaoling Chen, Chengbang Ma, Wei Li, Tianbao Chen, James F. Burrows, Lei Wang, Mei Zhou
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Pharmaceutics
Subjects:
Kunitz-type peptides
multifunctional peptides
secondary structure
antimicrobial activity in vitro and in vivo
antiproliferative activity
apoptosis
Online Access:https://www.mdpi.com/1999-4923/16/5/597

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https://www.mdpi.com/1999-4923/16/5/597

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