Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats.
As previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5085085?pdf=render |
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| author | Magdalena Bujalska-Zadrożny Kamila Kulik Michał Ordak Małgorzata Sasinowska-Motyl Emilia Gąsińska Anna de Corde Agnieszka Kowalczyk Mariusz Sacharczuk Marek Naruszewicz |
| author_facet | Magdalena Bujalska-Zadrożny Kamila Kulik Michał Ordak Małgorzata Sasinowska-Motyl Emilia Gąsińska Anna de Corde Agnieszka Kowalczyk Mariusz Sacharczuk Marek Naruszewicz |
| author_sort | Magdalena Bujalska-Zadrożny |
| collection | DOAJ |
| description | As previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could increase opioids induced antinociception.In behavioural studies on rats morphine, tramadol and oxycodone together with magnesium (lactate dihydrate, hydroaspartate, chloride) in micronized (particles of size D90 < 50 μm) and conventional forms were used. Changes in pain thresholds were determined using mechanical stimuli. The intestinal absorption of two forms of magnesium lactate dihydrate (at the doses of 7.5 or 15 mg ions) in the porcine gut sac model were also compared.Micronized form of magnesium lactate dihydrate or hydroaspartate but not chloride (15 mg of magnesium ions kg-1) enhanced the analgesic activity of orally administered opioids, significantly faster and more effective in comparison to the conventional form of magnesium salts (about 40% for oxycodone administered together with a micronized form of magnesium hydroaspartate). Moreover, in vitro studies of transport across porcine intestines of magnesium ions showed that magnesium salts administered in micronized form were absorbed from the intestines to a greater extent than the normal form of magnesium salts.The co-administration of micronized magnesium organic salts with opioids increased their synergetic analgesic effect. This may suggest an innovative approach to the treatment of pain in clinical practice. |
| first_indexed | 2024-12-14T14:22:18Z |
| format | Article |
| id | doaj.art-bbc070745fd848069c3892c01cd9b02a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T14:22:18Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bbc070745fd848069c3892c01cd9b02a2022-12-21T22:58:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016177610.1371/journal.pone.0161776Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats.Magdalena Bujalska-ZadrożnyKamila KulikMichał OrdakMałgorzata Sasinowska-MotylEmilia GąsińskaAnna de CordeAgnieszka KowalczykMariusz SacharczukMarek NaruszewiczAs previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could increase opioids induced antinociception.In behavioural studies on rats morphine, tramadol and oxycodone together with magnesium (lactate dihydrate, hydroaspartate, chloride) in micronized (particles of size D90 < 50 μm) and conventional forms were used. Changes in pain thresholds were determined using mechanical stimuli. The intestinal absorption of two forms of magnesium lactate dihydrate (at the doses of 7.5 or 15 mg ions) in the porcine gut sac model were also compared.Micronized form of magnesium lactate dihydrate or hydroaspartate but not chloride (15 mg of magnesium ions kg-1) enhanced the analgesic activity of orally administered opioids, significantly faster and more effective in comparison to the conventional form of magnesium salts (about 40% for oxycodone administered together with a micronized form of magnesium hydroaspartate). Moreover, in vitro studies of transport across porcine intestines of magnesium ions showed that magnesium salts administered in micronized form were absorbed from the intestines to a greater extent than the normal form of magnesium salts.The co-administration of micronized magnesium organic salts with opioids increased their synergetic analgesic effect. This may suggest an innovative approach to the treatment of pain in clinical practice.http://europepmc.org/articles/PMC5085085?pdf=render |
| spellingShingle | Magdalena Bujalska-Zadrożny Kamila Kulik Michał Ordak Małgorzata Sasinowska-Motyl Emilia Gąsińska Anna de Corde Agnieszka Kowalczyk Mariusz Sacharczuk Marek Naruszewicz Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. PLoS ONE |
| title | Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. |
| title_full | Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. |
| title_fullStr | Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. |
| title_full_unstemmed | Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. |
| title_short | Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats. |
| title_sort | micronized organic magnesium salts enhance opioid analgesia in rats |
| url | http://europepmc.org/articles/PMC5085085?pdf=render |
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