Remembering Mechanosensitivity of NMDA Receptors
An increase in post-synaptic Ca2+ conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-12-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00533/full |
| _version_ | 1818179640310628352 |
|---|---|
| author | Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Andrew R. Battle Andrew R. Battle Andrew R. Battle Boris Martinac Boris Martinac |
| author_facet | Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Andrew R. Battle Andrew R. Battle Andrew R. Battle Boris Martinac Boris Martinac |
| author_sort | Luke R. Johnson |
| collection | DOAJ |
| description | An increase in post-synaptic Ca2+ conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs in classical conditioning, where the NMDAR can act as a molecular coincidence detector. Binding of glutamate and glycine, together with depolarization of the postsynaptic cell membrane to remove the Mg2+ channel pore block, results in NMDAR opening for Ca2+ conductance. Accumulating evidence has implicated both force-from-lipids and protein tethering mechanisms for mechanosensory transduction in NMDAR, which has been demonstrated by both, membrane stretch and application of amphipathic molecules such as arachidonic acid (AA). The contribution of mechanosensitivity to memory formation and consolidation may be to increase activity of the NMDAR leading to facilitated memory formation. In this review we look back at the progress made toward understanding the physiological and pathological role of NMDA receptor channels in mechanobiology of the nervous system and consider these findings in like of their potential functional implications for memory formation. We examine recent studies identifying mechanisms of both NMDAR and other mechanosensitive channels and discuss functional implications including gain control of NMDA opening probability. Mechanobiology is a rapidly growing area of biology with many important implications for understanding form, function and pathology in the nervous system. |
| first_indexed | 2024-12-11T21:07:05Z |
| format | Article |
| id | doaj.art-bbc09976eb194d32926315cda93b469b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T21:07:05Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-bbc09976eb194d32926315cda93b469b2022-12-22T00:50:50ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-12-011310.3389/fncel.2019.00533487642Remembering Mechanosensitivity of NMDA ReceptorsLuke R. Johnson0Luke R. Johnson1Luke R. Johnson2Luke R. Johnson3Luke R. Johnson4Andrew R. Battle5Andrew R. Battle6Andrew R. Battle7Boris Martinac8Boris Martinac9Victor Chang Cardiac Research Institute, Darlinghurst, NSW, AustraliaSt. Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, AustraliaDivision of Psychology, School of Medicine, University of Tasmania, Launceston, TAS, AustraliaDepartment of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesSchool of Biomedical Sciences, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, QLD, AustraliaPrince Charles Hospital Northside Clinical Unit, School of Clinical Medicine, The University of Queensland, Brisbane, QLD, AustraliaTranslational Research Institute, Woolloongabba, QLD, AustraliaVictor Chang Cardiac Research Institute, Darlinghurst, NSW, AustraliaSt. Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, AustraliaAn increase in post-synaptic Ca2+ conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs in classical conditioning, where the NMDAR can act as a molecular coincidence detector. Binding of glutamate and glycine, together with depolarization of the postsynaptic cell membrane to remove the Mg2+ channel pore block, results in NMDAR opening for Ca2+ conductance. Accumulating evidence has implicated both force-from-lipids and protein tethering mechanisms for mechanosensory transduction in NMDAR, which has been demonstrated by both, membrane stretch and application of amphipathic molecules such as arachidonic acid (AA). The contribution of mechanosensitivity to memory formation and consolidation may be to increase activity of the NMDAR leading to facilitated memory formation. In this review we look back at the progress made toward understanding the physiological and pathological role of NMDA receptor channels in mechanobiology of the nervous system and consider these findings in like of their potential functional implications for memory formation. We examine recent studies identifying mechanisms of both NMDAR and other mechanosensitive channels and discuss functional implications including gain control of NMDA opening probability. Mechanobiology is a rapidly growing area of biology with many important implications for understanding form, function and pathology in the nervous system.https://www.frontiersin.org/article/10.3389/fncel.2019.00533/fullmemorylearningNMDAmechanobiologyamygdalaforce |
| spellingShingle | Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Luke R. Johnson Andrew R. Battle Andrew R. Battle Andrew R. Battle Boris Martinac Boris Martinac Remembering Mechanosensitivity of NMDA Receptors Frontiers in Cellular Neuroscience memory learning NMDA mechanobiology amygdala force |
| title | Remembering Mechanosensitivity of NMDA Receptors |
| title_full | Remembering Mechanosensitivity of NMDA Receptors |
| title_fullStr | Remembering Mechanosensitivity of NMDA Receptors |
| title_full_unstemmed | Remembering Mechanosensitivity of NMDA Receptors |
| title_short | Remembering Mechanosensitivity of NMDA Receptors |
| title_sort | remembering mechanosensitivity of nmda receptors |
| topic | memory learning NMDA mechanobiology amygdala force |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00533/full |
| work_keys_str_mv | AT lukerjohnson rememberingmechanosensitivityofnmdareceptors AT lukerjohnson rememberingmechanosensitivityofnmdareceptors AT lukerjohnson rememberingmechanosensitivityofnmdareceptors AT lukerjohnson rememberingmechanosensitivityofnmdareceptors AT lukerjohnson rememberingmechanosensitivityofnmdareceptors AT andrewrbattle rememberingmechanosensitivityofnmdareceptors AT andrewrbattle rememberingmechanosensitivityofnmdareceptors AT andrewrbattle rememberingmechanosensitivityofnmdareceptors AT borismartinac rememberingmechanosensitivityofnmdareceptors AT borismartinac rememberingmechanosensitivityofnmdareceptors |