Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis
Introduction: Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14). Methods: Expression levels of MAPK14 and its associa...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000227 |
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| author | Soudeh Ghafouri-Fard Mahdi Gholipour Solat Eslami Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian Mir Davood Omrani |
| author_facet | Soudeh Ghafouri-Fard Mahdi Gholipour Solat Eslami Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian Mir Davood Omrani |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Introduction: Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14). Methods: Expression levels of MAPK14 and its associated lncRNAs were measured in the circulation of MS patients compared with control subjects. Results: Expression levels of NORAD and RAD51-AS1 were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04–1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43–2.6), P value = 0.0001, respectively). Conversely, ZNRD1ASP was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41–0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset. Conclusion: To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients. |
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| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:26:11Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-bbc2134f2b1a45c3bc0d997ae677ef822024-04-16T22:16:16ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-09-0183335339Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosisSoudeh Ghafouri-Fard0Mahdi Gholipour1Solat Eslami2Bashdar Mahmud Hussen3Mohammad Taheri4Mohammad Samadian5Mir Davood Omrani6Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, IranDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, IraqUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Institute of Human Genetics, Jena University Hospital, Jena, Germany; Corresponding author. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Neurosurgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Introduction: Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14). Methods: Expression levels of MAPK14 and its associated lncRNAs were measured in the circulation of MS patients compared with control subjects. Results: Expression levels of NORAD and RAD51-AS1 were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04–1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43–2.6), P value = 0.0001, respectively). Conversely, ZNRD1ASP was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41–0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset. Conclusion: To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients.http://www.sciencedirect.com/science/article/pii/S2468054023000227Multiple sclerosislncRNANORADHCG11ZNRD1ASPRAD51-AS1 |
| spellingShingle | Soudeh Ghafouri-Fard Mahdi Gholipour Solat Eslami Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian Mir Davood Omrani Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis Non-coding RNA Research Multiple sclerosis lncRNA NORAD HCG11 ZNRD1ASP RAD51-AS1 |
| title | Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis |
| title_full | Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis |
| title_fullStr | Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis |
| title_full_unstemmed | Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis |
| title_short | Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis |
| title_sort | abnormal expression of mapk14 related lncrnas in the peripheral blood of patients with multiple sclerosis |
| topic | Multiple sclerosis lncRNA NORAD HCG11 ZNRD1ASP RAD51-AS1 |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000227 |
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