Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait
IntroductionCoordinated Reset Deep Brain Stimulation (CR DBS) is a novel DBS approach for treating Parkinson's disease (PD) that uses lower levels of burst stimulation through multiple contacts of the DBS lead. Though CR DBS has been demonstrated to have sustained therapeutic effects on rigidit...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neuroinformatics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fninf.2023.1185723/full |
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| author | Kai M. Bosley Ziling Luo Sana Amoozegar Kit Acedillo Kanon Nakajima Luke A. Johnson Jerrold L. Vitek Jing Wang |
| author_facet | Kai M. Bosley Ziling Luo Sana Amoozegar Kit Acedillo Kanon Nakajima Luke A. Johnson Jerrold L. Vitek Jing Wang |
| author_sort | Kai M. Bosley |
| collection | DOAJ |
| description | IntroductionCoordinated Reset Deep Brain Stimulation (CR DBS) is a novel DBS approach for treating Parkinson's disease (PD) that uses lower levels of burst stimulation through multiple contacts of the DBS lead. Though CR DBS has been demonstrated to have sustained therapeutic effects on rigidity, tremor, bradykinesia, and akinesia following cessation of stimulation, i.e., carryover effect, its effect on Parkinsonian gait has not been well studied. Impaired gait is a disabling symptom of PD, often associated with a higher risk of falling and a reduced quality of life. The goal of this study was to explore the carryover effect of subthalamic CR DBS on Parkinsonian gait.MethodsThree non-human primates (NHPs) were rendered Parkinsonian and implanted with a DBS lead in the subthalamic nucleus (STN). For each animal, STN CR DBS was delivered for several hours per day across five consecutive days. A clinical rating scale modified for NHP use (mUPDRS) was administered every morning to monitor the carryover effect of CR DBS on rigidity, tremor, akinesia, and bradykinesia. Gait was assessed quantitatively before and after STN CR DBS. The stride length and swing speed were calculated and compared to the baseline, pre-stimulation condition.ResultsIn all three animals, carryover improvements in rigidity, bradykinesia, and akinesia were observed after CR DBS. Increased swing speed was observed in all the animals; however, improvement in stride length was only observed in NHP B2. In addition, STN CR DBS using two different burst frequencies was evaluated in NHP B2, and differential effects on the mUPDRS score and gait were observed.DiscussionAlthough preliminary, our results indicate that STN CR DBS can improve Parkinsonian gait together with other motor signs when stimulation parameters are properly selected. This study further supports the continued development of CR DBS as a novel therapy for PD and highlights the importance of parameter selection in its clinical application. |
| first_indexed | 2024-03-12T13:30:46Z |
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| id | doaj.art-bbc30ce352994a1eb70e2f383e500b0c |
| institution | Directory Open Access Journal |
| issn | 1662-5196 |
| language | English |
| last_indexed | 2024-03-12T13:30:46Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroinformatics |
| spelling | doaj.art-bbc30ce352994a1eb70e2f383e500b0c2023-08-24T15:17:02ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962023-08-011710.3389/fninf.2023.11857231185723Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gaitKai M. Bosley0Ziling Luo1Sana Amoozegar2Kit Acedillo3Kanon Nakajima4Luke A. Johnson5Jerrold L. Vitek6Jing Wang7Department of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesNeuroscience Program, Macalester College, Saint Paul, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesIntroductionCoordinated Reset Deep Brain Stimulation (CR DBS) is a novel DBS approach for treating Parkinson's disease (PD) that uses lower levels of burst stimulation through multiple contacts of the DBS lead. Though CR DBS has been demonstrated to have sustained therapeutic effects on rigidity, tremor, bradykinesia, and akinesia following cessation of stimulation, i.e., carryover effect, its effect on Parkinsonian gait has not been well studied. Impaired gait is a disabling symptom of PD, often associated with a higher risk of falling and a reduced quality of life. The goal of this study was to explore the carryover effect of subthalamic CR DBS on Parkinsonian gait.MethodsThree non-human primates (NHPs) were rendered Parkinsonian and implanted with a DBS lead in the subthalamic nucleus (STN). For each animal, STN CR DBS was delivered for several hours per day across five consecutive days. A clinical rating scale modified for NHP use (mUPDRS) was administered every morning to monitor the carryover effect of CR DBS on rigidity, tremor, akinesia, and bradykinesia. Gait was assessed quantitatively before and after STN CR DBS. The stride length and swing speed were calculated and compared to the baseline, pre-stimulation condition.ResultsIn all three animals, carryover improvements in rigidity, bradykinesia, and akinesia were observed after CR DBS. Increased swing speed was observed in all the animals; however, improvement in stride length was only observed in NHP B2. In addition, STN CR DBS using two different burst frequencies was evaluated in NHP B2, and differential effects on the mUPDRS score and gait were observed.DiscussionAlthough preliminary, our results indicate that STN CR DBS can improve Parkinsonian gait together with other motor signs when stimulation parameters are properly selected. This study further supports the continued development of CR DBS as a novel therapy for PD and highlights the importance of parameter selection in its clinical application.https://www.frontiersin.org/articles/10.3389/fninf.2023.1185723/fullParkinson's diseasesubthalamic nucleuscoordinated resetgaitnon-human primate |
| spellingShingle | Kai M. Bosley Ziling Luo Sana Amoozegar Kit Acedillo Kanon Nakajima Luke A. Johnson Jerrold L. Vitek Jing Wang Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait Frontiers in Neuroinformatics Parkinson's disease subthalamic nucleus coordinated reset gait non-human primate |
| title | Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait |
| title_full | Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait |
| title_fullStr | Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait |
| title_full_unstemmed | Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait |
| title_short | Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait |
| title_sort | effect of subthalamic coordinated reset deep brain stimulation on parkinsonian gait |
| topic | Parkinson's disease subthalamic nucleus coordinated reset gait non-human primate |
| url | https://www.frontiersin.org/articles/10.3389/fninf.2023.1185723/full |
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