TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis

TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis

Abstract Background The transforming growth factor-beta (TGF-β) signaling pathway is an important pathway associated with the pathogenesis of osteoarthritis (OA). This study was to investigate the involvement of circRNAs in the TGF-β signaling pathway. Methods Cell Counting Kit-8 (CCK-8) assay and 5...

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Bibliographic Details
Main Authors: Shiyuan Lin, Huizi Li, Biao Wu, Jie Shang, Ning Jiang, Rong Peng, Baizhou Xing, Xianghe Xu, Huading Lu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell Communication and Signaling
Subjects:
Chondrocyte
circRNA
Osteoarthritis
TGF-β1
Vegfa
Online Access:https://doi.org/10.1186/s12964-022-00881-9

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