Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Abstract Background Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndrome (ARDS) in recent years. However, the role of hemoadsorption in ARDS patients requiring VV ECMO is unclear. Methods Therefore, we conducted a systematic rev...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-024-02675-8 |
| _version_ | 1797355599984328704 |
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| author | Wenli Li Yuansen Chen Duo Li Xiangyan Meng Ziquan Liu Yanqing Liu Haojun Fan |
| author_facet | Wenli Li Yuansen Chen Duo Li Xiangyan Meng Ziquan Liu Yanqing Liu Haojun Fan |
| author_sort | Wenli Li |
| collection | DOAJ |
| description | Abstract Background Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndrome (ARDS) in recent years. However, the role of hemoadsorption in ARDS patients requiring VV ECMO is unclear. Methods Therefore, we conducted a systematic review to describe the effect of hemoadsorption on outcomes of ARDS patients requiring VV ECMO and elucidate the risk factors for adverse outcomes. We conducted and reported a systematic literature review based on the principles derived from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The systematic review searched Embase, CINHAL, and Pubmed databases for studies on ARDS patients receiving hemoadsorption and VV ECMO. The demographic data, clinical data and biological data of the patients were collected. Results We ultimately included a total of 8 articles including 189 patients. We characterized the population both clinically and biologically. Our review showed most studies described reductions in inflammatory markers and fluid resuscitation drug dosage in ARDS patients with Coronavirus disease 2019 (COVID-19) or sepsis after hemoadsorption. Conclusion Because most of the studies have the characteristics of high heterogeneity, we could only draw very cautious conclusions that hemoadsorption therapy may enhance hemodynamic stability in ARDS patients with COVID-19 or sepsis receiving VV ECMO support. However, our results do not allow us to draw conclusions that hemoadsorption could reduce inflammation and mortality. Prospective randomized controlled studies with a larger sample size are needed in the future to verify the role of hemoadsorption in ARDS patients requiring VV ECMO. |
| first_indexed | 2024-03-08T14:13:29Z |
| format | Article |
| id | doaj.art-bbc7ef92bca04350b2e299c8aa1181d8 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-08T14:13:29Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-bbc7ef92bca04350b2e299c8aa1181d82024-01-14T12:33:40ZengBMCRespiratory Research1465-993X2024-01-0125111110.1186/s12931-024-02675-8Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic reviewWenli Li0Yuansen Chen1Duo Li2Xiangyan Meng3Ziquan Liu4Yanqing Liu5Haojun Fan6Institute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityInstitute of Disaster and Emergency Medicine, Tianjin UniversityAbstract Background Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndrome (ARDS) in recent years. However, the role of hemoadsorption in ARDS patients requiring VV ECMO is unclear. Methods Therefore, we conducted a systematic review to describe the effect of hemoadsorption on outcomes of ARDS patients requiring VV ECMO and elucidate the risk factors for adverse outcomes. We conducted and reported a systematic literature review based on the principles derived from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The systematic review searched Embase, CINHAL, and Pubmed databases for studies on ARDS patients receiving hemoadsorption and VV ECMO. The demographic data, clinical data and biological data of the patients were collected. Results We ultimately included a total of 8 articles including 189 patients. We characterized the population both clinically and biologically. Our review showed most studies described reductions in inflammatory markers and fluid resuscitation drug dosage in ARDS patients with Coronavirus disease 2019 (COVID-19) or sepsis after hemoadsorption. Conclusion Because most of the studies have the characteristics of high heterogeneity, we could only draw very cautious conclusions that hemoadsorption therapy may enhance hemodynamic stability in ARDS patients with COVID-19 or sepsis receiving VV ECMO support. However, our results do not allow us to draw conclusions that hemoadsorption could reduce inflammation and mortality. Prospective randomized controlled studies with a larger sample size are needed in the future to verify the role of hemoadsorption in ARDS patients requiring VV ECMO.https://doi.org/10.1186/s12931-024-02675-8HemoadsorptionVenovenous extracorporeal membrane oxygenationAcute respiratory distress syndromeInflammationMortalityHemodynamic stability |
| spellingShingle | Wenli Li Yuansen Chen Duo Li Xiangyan Meng Ziquan Liu Yanqing Liu Haojun Fan Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review Respiratory Research Hemoadsorption Venovenous extracorporeal membrane oxygenation Acute respiratory distress syndrome Inflammation Mortality Hemodynamic stability |
| title | Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review |
| title_full | Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review |
| title_fullStr | Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review |
| title_full_unstemmed | Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review |
| title_short | Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review |
| title_sort | hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation a systematic review |
| topic | Hemoadsorption Venovenous extracorporeal membrane oxygenation Acute respiratory distress syndrome Inflammation Mortality Hemodynamic stability |
| url | https://doi.org/10.1186/s12931-024-02675-8 |
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