Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy
The nucleus is not only the control hub of cell life activities, but also the center of storing and controlling genetic information. The morphology of the nucleus can be used to judge the cell vitality and health. The various biological molecules contained in the nucleus are closely related to the n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/11/2/125 |
| _version_ | 1797621739069374464 |
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| author | Cong Hu Shuai Xu Zhiling Song Haixia Li Hongwen Liu |
| author_facet | Cong Hu Shuai Xu Zhiling Song Haixia Li Hongwen Liu |
| author_sort | Cong Hu |
| collection | DOAJ |
| description | The nucleus is not only the control hub of cell life activities, but also the center of storing and controlling genetic information. The morphology of the nucleus can be used to judge the cell vitality and health. The various biological molecules contained in the nucleus are closely related to the normal life activities, occurrence and development of diseases. In recent years, fluorescence imaging has gained increasing attention due to its advantages of being intuitive, in situ and visual. The development of fluorescent probes for high-resolution imaging of the nucleus and detection of biomolecules in the nucleus is of great value for understanding the normal physiological processes of cells or organisms, as well as for disease diagnosis and treatment. In this review, we mainly introduce the current general strategies for designing nucleus-targeted fluorescent probes, as well as their applications in nucleus-targeted imaging, intranuclear biomolecular detection and therapy. Moreover, we also discuss the current challenges and opportunities of nucleus-targeted fluorescent probes in terms of selectivity, design strategies and so on. |
| first_indexed | 2024-03-11T09:00:13Z |
| format | Article |
| id | doaj.art-bbcab08c502d455583da23c98957b8b4 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T09:00:13Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-bbcab08c502d455583da23c98957b8b42023-11-16T19:46:38ZengMDPI AGChemosensors2227-90402023-02-0111212510.3390/chemosensors11020125Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and TherapyCong Hu0Shuai Xu1Zhiling Song2Haixia Li3Hongwen Liu4Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410082, ChinaSchool of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, ChinaShandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, ChinaKey Laboratory of Chemical Biology and Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410082, ChinaKey Laboratory of Chemical Biology and Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410082, ChinaThe nucleus is not only the control hub of cell life activities, but also the center of storing and controlling genetic information. The morphology of the nucleus can be used to judge the cell vitality and health. The various biological molecules contained in the nucleus are closely related to the normal life activities, occurrence and development of diseases. In recent years, fluorescence imaging has gained increasing attention due to its advantages of being intuitive, in situ and visual. The development of fluorescent probes for high-resolution imaging of the nucleus and detection of biomolecules in the nucleus is of great value for understanding the normal physiological processes of cells or organisms, as well as for disease diagnosis and treatment. In this review, we mainly introduce the current general strategies for designing nucleus-targeted fluorescent probes, as well as their applications in nucleus-targeted imaging, intranuclear biomolecular detection and therapy. Moreover, we also discuss the current challenges and opportunities of nucleus-targeted fluorescent probes in terms of selectivity, design strategies and so on.https://www.mdpi.com/2227-9040/11/2/125nucleus-targetedfluorescent probesbioimagingdetectiontherapy |
| spellingShingle | Cong Hu Shuai Xu Zhiling Song Haixia Li Hongwen Liu Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy Chemosensors nucleus-targeted fluorescent probes bioimaging detection therapy |
| title | Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy |
| title_full | Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy |
| title_fullStr | Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy |
| title_full_unstemmed | Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy |
| title_short | Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy |
| title_sort | recent advance in nucleus targeted fluorescent probes for bioimaging detection and therapy |
| topic | nucleus-targeted fluorescent probes bioimaging detection therapy |
| url | https://www.mdpi.com/2227-9040/11/2/125 |
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