Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography
Background: Diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) present the ability to selectively protect functional regions and fiber tracts of the brain when brain tumors are treated with radiotherapy. Objective: This study aimed to assess whether the incorporation of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2023-06-01
|
| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | https://jbpe.sums.ac.ir/article_49291_1c48d8fe033fd6c1e1afa8af9919849f.pdf |
| _version_ | 1797807134600069120 |
|---|---|
| author | Arman Boroun Hamid Gholamhosseinian Alireza Montazerabadi Seyed Hadi Molana Fakhereh Pashaei |
| author_facet | Arman Boroun Hamid Gholamhosseinian Alireza Montazerabadi Seyed Hadi Molana Fakhereh Pashaei |
| author_sort | Arman Boroun |
| collection | DOAJ |
| description | Background: Diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) present the ability to selectively protect functional regions and fiber tracts of the brain when brain tumors are treated with radiotherapy.
Objective: This study aimed to assess whether the incorporation of fMRI and DTI data into the radiation treatment planning process of brain tumors could prevent the neurological parts of the brain from high doses of radiation.
Material and Methods: In this investigational theoretical study, the fMRI and DTI data were obtained from eight glioma patients. This patient-specific fMRI and DTI data were attained based on tumor location, the patient’s general conditions, and the importance of the functional and fiber tract areas. The functional regions, fiber tracts, anatomical organs at risk, and the tumor were contoured for radiation treatment planning. Finally, the radiation treatment planning with and without fMRI & DTI information was obtained and compared.
Results: The mean dose to the functional areas and the maximum doses were reduced by 25.36% and 18.57% on fMRI & DTI plans compared with the anatomical plans. In addition, 15.59% and 20.84% reductions were achieved in the mean and maximum doses of the fiber tracts, respectively.
Conclusion: This study demonstrated the feasibility of using fMRI and DTI data in radiation treatment planning to maximize radiation protection of the functional cortex and fiber tracts. The mean and maximum doses significantly decreased to neurologically relevant brain regions, resulting in reducing the neuro-cognitive complications and improving the patient’s quality of life. |
| first_indexed | 2024-03-13T06:17:59Z |
| format | Article |
| id | doaj.art-bbcb1755fd58480d9485bd764f5ff4d9 |
| institution | Directory Open Access Journal |
| issn | 2251-7200 |
| language | English |
| last_indexed | 2024-03-13T06:17:59Z |
| publishDate | 2023-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Biomedical Physics and Engineering |
| spelling | doaj.art-bbcb1755fd58480d9485bd764f5ff4d92023-06-10T10:41:57ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002023-06-0113323925010.31661/jbpe.v0i0.2210-154749291Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter TractographyArman Boroun0Hamid Gholamhosseinian1Alireza Montazerabadi2Seyed Hadi Molana3Fakhereh Pashaei4Radiation Sciences Research Center (RSRC), Aja University of Medical Sciences, Tehran, IranMedical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, IranMedical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Radiation Oncology, Aja University of Medical Sciences, Tehran, IranRadiation Sciences Research Center (RSRC), Aja University of Medical Sciences, Tehran, IranBackground: Diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) present the ability to selectively protect functional regions and fiber tracts of the brain when brain tumors are treated with radiotherapy. Objective: This study aimed to assess whether the incorporation of fMRI and DTI data into the radiation treatment planning process of brain tumors could prevent the neurological parts of the brain from high doses of radiation. Material and Methods: In this investigational theoretical study, the fMRI and DTI data were obtained from eight glioma patients. This patient-specific fMRI and DTI data were attained based on tumor location, the patient’s general conditions, and the importance of the functional and fiber tract areas. The functional regions, fiber tracts, anatomical organs at risk, and the tumor were contoured for radiation treatment planning. Finally, the radiation treatment planning with and without fMRI & DTI information was obtained and compared. Results: The mean dose to the functional areas and the maximum doses were reduced by 25.36% and 18.57% on fMRI & DTI plans compared with the anatomical plans. In addition, 15.59% and 20.84% reductions were achieved in the mean and maximum doses of the fiber tracts, respectively. Conclusion: This study demonstrated the feasibility of using fMRI and DTI data in radiation treatment planning to maximize radiation protection of the functional cortex and fiber tracts. The mean and maximum doses significantly decreased to neurologically relevant brain regions, resulting in reducing the neuro-cognitive complications and improving the patient’s quality of life.https://jbpe.sums.ac.ir/article_49291_1c48d8fe033fd6c1e1afa8af9919849f.pdfbrain neoplasmsfmridiffusion tensor imagingradiation therapygliomamri |
| spellingShingle | Arman Boroun Hamid Gholamhosseinian Alireza Montazerabadi Seyed Hadi Molana Fakhereh Pashaei Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography Journal of Biomedical Physics and Engineering brain neoplasms fmri diffusion tensor imaging radiation therapy glioma mri |
| title | Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography |
| title_full | Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography |
| title_fullStr | Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography |
| title_full_unstemmed | Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography |
| title_short | Optimizing the Radiation Treatment Planning of Brain Tumors by Integration of Functional MRI and White Matter Tractography |
| title_sort | optimizing the radiation treatment planning of brain tumors by integration of functional mri and white matter tractography |
| topic | brain neoplasms fmri diffusion tensor imaging radiation therapy glioma mri |
| url | https://jbpe.sums.ac.ir/article_49291_1c48d8fe033fd6c1e1afa8af9919849f.pdf |
| work_keys_str_mv | AT armanboroun optimizingtheradiationtreatmentplanningofbraintumorsbyintegrationoffunctionalmriandwhitemattertractography AT hamidgholamhosseinian optimizingtheradiationtreatmentplanningofbraintumorsbyintegrationoffunctionalmriandwhitemattertractography AT alirezamontazerabadi optimizingtheradiationtreatmentplanningofbraintumorsbyintegrationoffunctionalmriandwhitemattertractography AT seyedhadimolana optimizingtheradiationtreatmentplanningofbraintumorsbyintegrationoffunctionalmriandwhitemattertractography AT fakherehpashaei optimizingtheradiationtreatmentplanningofbraintumorsbyintegrationoffunctionalmriandwhitemattertractography |