Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida
Objective To determine the predictive value of plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) ratio for detection of preeclampsia in elderly gravida at 16–18 weeks of gestation and to identify whether abnormalities of this ratio are associated with any other pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2020.1745227 |
| _version_ | 1827814527375245312 |
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| author | Vorapong Phupong Wilasinee Areeruk Patau Tantbirojn Ruangsak Lertkhachonsuk |
| author_facet | Vorapong Phupong Wilasinee Areeruk Patau Tantbirojn Ruangsak Lertkhachonsuk |
| author_sort | Vorapong Phupong |
| collection | DOAJ |
| description | Objective To determine the predictive value of plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) ratio for detection of preeclampsia in elderly gravida at 16–18 weeks of gestation and to identify whether abnormalities of this ratio are associated with any other pregnancy complications or not. Methods Blood samples of 300 cases were collected. Plasma sFlt-1 and PlGF levels were measured using an automated immunoassay. Results Sensitivity and specificity for plasma sFlt-1/PlGF ratio above 9.8 for preeclampsia prediction were 85.7% and 61.2%, respectively. The sensitivity and specificity to predict early onset preeclampsia were 100% and 61.1%, respectively. Women with abnormal plasma sFlt-1/PlGF ratio were not associated with any other pregnancy complications. Conclusion sFlt-1/PlGF ratio at 16–18 weeks of gestation in elderly gravida has a high sensitivity for predicting preeclampsia, especially early onset preeclampsia. |
| first_indexed | 2024-03-11T23:46:20Z |
| format | Article |
| id | doaj.art-bbcb72a5f2904a6d9088ed3c59cf460c |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:20Z |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-bbcb72a5f2904a6d9088ed3c59cf460c2023-09-19T09:24:43ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652020-04-0139213914410.1080/10641955.2020.17452271745227Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravidaVorapong Phupong0Wilasinee Areeruk1Patau Tantbirojn2Ruangsak Lertkhachonsuk3Chulalongkorn UniversityChulalongkorn UniversityChulalongkorn UniversityChulalongkorn UniversityObjective To determine the predictive value of plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) ratio for detection of preeclampsia in elderly gravida at 16–18 weeks of gestation and to identify whether abnormalities of this ratio are associated with any other pregnancy complications or not. Methods Blood samples of 300 cases were collected. Plasma sFlt-1 and PlGF levels were measured using an automated immunoassay. Results Sensitivity and specificity for plasma sFlt-1/PlGF ratio above 9.8 for preeclampsia prediction were 85.7% and 61.2%, respectively. The sensitivity and specificity to predict early onset preeclampsia were 100% and 61.1%, respectively. Women with abnormal plasma sFlt-1/PlGF ratio were not associated with any other pregnancy complications. Conclusion sFlt-1/PlGF ratio at 16–18 weeks of gestation in elderly gravida has a high sensitivity for predicting preeclampsia, especially early onset preeclampsia.http://dx.doi.org/10.1080/10641955.2020.1745227preeclampsiasoluble fms-like tyrosine kinase 1placental growth factorratioelderly gravida |
| spellingShingle | Vorapong Phupong Wilasinee Areeruk Patau Tantbirojn Ruangsak Lertkhachonsuk Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida Hypertension in Pregnancy preeclampsia soluble fms-like tyrosine kinase 1 placental growth factor ratio elderly gravida |
| title | Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| title_full | Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| title_fullStr | Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| title_full_unstemmed | Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| title_short | Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| title_sort | soluble fms like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida |
| topic | preeclampsia soluble fms-like tyrosine kinase 1 placental growth factor ratio elderly gravida |
| url | http://dx.doi.org/10.1080/10641955.2020.1745227 |
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