The role of vitamin D in seasonal acute respiratory viral infections and COVID-19
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2020-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/56945/40135 |
| _version_ | 1818328741351260160 |
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| author | E. A. Pigarova A. A. Povalyaeva L. K. Dzeranova L. Y. Rozhinskaya N. G. Mokrysheva |
| author_facet | E. A. Pigarova A. A. Povalyaeva L. K. Dzeranova L. Y. Rozhinskaya N. G. Mokrysheva |
| author_sort | E. A. Pigarova |
| collection | DOAJ |
| description | A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19. |
| first_indexed | 2024-12-13T12:36:59Z |
| format | Article |
| id | doaj.art-bbcb8f3a1c0a44cdb8d4c8be4ff80811 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T12:36:59Z |
| publishDate | 2020-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-bbcb8f3a1c0a44cdb8d4c8be4ff808112022-12-21T23:45:48Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-12-0192119810510.26442/00403660.2020.11.00078552123The role of vitamin D in seasonal acute respiratory viral infections and COVID-19E. A. Pigarova0A. A. Povalyaeva1L. K. Dzeranova2L. Y. Rozhinskaya3N. G. Mokrysheva4Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreA link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19.https://ter-arkhiv.ru/0040-3660/article/viewFile/56945/40135vitamin dcholecalciferolcovid-19coronavirus infectionvdrimmunityacute respiratory distress syndromecyp28b1 |
| spellingShingle | E. A. Pigarova A. A. Povalyaeva L. K. Dzeranova L. Y. Rozhinskaya N. G. Mokrysheva The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 Терапевтический архив vitamin d cholecalciferol covid-19 coronavirus infection vdr immunity acute respiratory distress syndrome cyp28b1 |
| title | The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
| title_full | The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
| title_fullStr | The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
| title_full_unstemmed | The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
| title_short | The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
| title_sort | role of vitamin d in seasonal acute respiratory viral infections and covid 19 |
| topic | vitamin d cholecalciferol covid-19 coronavirus infection vdr immunity acute respiratory distress syndrome cyp28b1 |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/56945/40135 |
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