Two Cases of Allergy to Insulin in Gestational Diabetes
Allergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy. Herein, we report two cases of allergic reaction to insulin in gestational diabetes that w...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2015-09-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-402.pdf |
| _version_ | 1811331668923908096 |
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| author | Gi Jun Kim Shin Bum Kim Seong Il Jo Jin Kyeong Shin Hee Sun Kwon Heekyung Jeong Jang Won Son Seong Su Lee Sung Rae Kim Byung Kee Kim Soon Jib Yoo |
| author_facet | Gi Jun Kim Shin Bum Kim Seong Il Jo Jin Kyeong Shin Hee Sun Kwon Heekyung Jeong Jang Won Son Seong Su Lee Sung Rae Kim Byung Kee Kim Soon Jib Yoo |
| author_sort | Gi Jun Kim |
| collection | DOAJ |
| description | Allergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy. Herein, we report two cases of allergic reaction to insulin in gestational diabetes that were successfully managed. One case was a 33-year-old female using isophane-neutral protamine Hagedorn human insulin and insulin lispro. She experienced dyspnea, cough, urticaria and itching sensation at the sites of insulin injection immediately after insulin administration. We discontinued insulin therapy and started oral hypoglycemic agents with metformin and glibenclamide. The other case was a 32-year-old female using insulin lispro and insulin detemer. She experienced pruritus and burning sensation and multiple nodules at the sites of insulin injection. We changed the insulin from insulin lispro to insulin aspart. Assessments including immunoglobulin E (IgE), IgG, eosinophil, insulin antibody level and skin biopsy were performed. In the two cases, the symptoms were resolved after changing the insulin to oral agents or other insulin preparations. We report two cases of allergic reaction to human insulin in gestational diabetes due to its rarity. |
| first_indexed | 2024-04-13T16:25:05Z |
| format | Article |
| id | doaj.art-bbcbc607d8ae43eebed39b626e7ac3bf |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T16:25:05Z |
| publishDate | 2015-09-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-bbcbc607d8ae43eebed39b626e7ac3bf2022-12-22T02:39:47ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-09-0130340240710.3803/EnM.2015.30.3.40220836Two Cases of Allergy to Insulin in Gestational DiabetesGi Jun KimShin Bum KimSeong Il JoJin Kyeong ShinHee Sun KwonHeekyung JeongJang Won SonSeong Su LeeSung Rae KimByung Kee KimSoon Jib YooAllergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy. Herein, we report two cases of allergic reaction to insulin in gestational diabetes that were successfully managed. One case was a 33-year-old female using isophane-neutral protamine Hagedorn human insulin and insulin lispro. She experienced dyspnea, cough, urticaria and itching sensation at the sites of insulin injection immediately after insulin administration. We discontinued insulin therapy and started oral hypoglycemic agents with metformin and glibenclamide. The other case was a 32-year-old female using insulin lispro and insulin detemer. She experienced pruritus and burning sensation and multiple nodules at the sites of insulin injection. We changed the insulin from insulin lispro to insulin aspart. Assessments including immunoglobulin E (IgE), IgG, eosinophil, insulin antibody level and skin biopsy were performed. In the two cases, the symptoms were resolved after changing the insulin to oral agents or other insulin preparations. We report two cases of allergic reaction to human insulin in gestational diabetes due to its rarity.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-402.pdfInsulin allergyDiabetes, gestationalHypersensitivity, immediate |
| spellingShingle | Gi Jun Kim Shin Bum Kim Seong Il Jo Jin Kyeong Shin Hee Sun Kwon Heekyung Jeong Jang Won Son Seong Su Lee Sung Rae Kim Byung Kee Kim Soon Jib Yoo Two Cases of Allergy to Insulin in Gestational Diabetes Endocrinology and Metabolism Insulin allergy Diabetes, gestational Hypersensitivity, immediate |
| title | Two Cases of Allergy to Insulin in Gestational Diabetes |
| title_full | Two Cases of Allergy to Insulin in Gestational Diabetes |
| title_fullStr | Two Cases of Allergy to Insulin in Gestational Diabetes |
| title_full_unstemmed | Two Cases of Allergy to Insulin in Gestational Diabetes |
| title_short | Two Cases of Allergy to Insulin in Gestational Diabetes |
| title_sort | two cases of allergy to insulin in gestational diabetes |
| topic | Insulin allergy Diabetes, gestational Hypersensitivity, immediate |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-402.pdf |
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