Amplified Host Defense by Toll-Like Receptor-Mediated Downregulation of the Glucocorticoid-Induced Leucine Zipper (GILZ) in Macrophages

Amplified Host Defense by Toll-Like Receptor-Mediated Downregulation of the Glucocorticoid-Induced Leucine Zipper (GILZ) in Macrophages

Activation of toll-like receptors (TLRs) plays a pivotal role in the host defense against bacteria and results in the activation of NF-κB-mediated transcription of proinflammatory mediators. Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory mediator, which inhibits NF-κB activity...

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Bibliographic Details
Main Authors: Jessica Hoppstädter, Britta Diesel, Rebecca Linnenberger, Nina Hachenthal, Sara Flamini, Marie Minet, Petra Leidinger, Christina Backes, Friedrich Grässer, Eckart Meese, Stefano Bruscoli, Carlo Riccardi, Hanno Huwer, Alexandra K. Kiemer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
inflammation
MyD88
TRIF
NF-κB
cytokine
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03111/full

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