Hepatocyte-Specific <i>Phgdh</i>-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation

Hepatocyte-Specific <i>Phgdh</i>-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation

<span style="font-variant: small-caps;">l</span>-Serine (Ser) is synthesized de novo from 3-phosphoglycerate via the phosphorylated pathway committed by phosphoglycerate dehydrogenase (<i>Phgdh</i>). A previous study reported that feeding a protein-free diet increas...

Full description

Bibliographic Details
Main Authors: Momoko Hamano, Kayoko Esaki, Kazuki Moriyasu, Tokio Yasuda, Sinya Mohri, Kosuke Tashiro, Yoshio Hirabayashi, Shigeki Furuya
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Nutrients
Subjects:
<i>Phgdh</i>
liver
<span style="font-variant: small-caps">l</span>-serine deficiency
insulin signaling
glucose tolerance
Online Access:https://www.mdpi.com/2072-6643/13/10/3468

Similar Items

Similar Items