Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs

Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs

Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to some extent from conventional two-chain Fv fra...

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Bibliographic Details
Main Authors: Francis Gaudreault, Christopher R. Corbeil, Enrico O. Purisima, Traian Sulea
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
single-domain antibody
CDR prediction
antibody design
canonical structure
structural determinants
sequence preferences
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884132/full

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