Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration
Purpose: The formation of macular hole after receiving anti-vascular endothelial growth factor (anti-VEGF) therapy is rare. We report a case of macular hole that occurred after intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD) in a patient, who underwent vitrect...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199361730172X |
| _version_ | 1818929567629312000 |
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| author | Akira Hirata Ken Hayashi Kazuhisa Murata Kei-ichiro Nakamura |
| author_facet | Akira Hirata Ken Hayashi Kazuhisa Murata Kei-ichiro Nakamura |
| author_sort | Akira Hirata |
| collection | DOAJ |
| description | Purpose: The formation of macular hole after receiving anti-vascular endothelial growth factor (anti-VEGF) therapy is rare. We report a case of macular hole that occurred after intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD) in a patient, who underwent vitrectomy combined with choroidal neovascularization (CNV) removal.
Observations: A 64-year-old female with AMD affecting her right eye received an intravitreal injection of an anti-VEGF agent. After treatment, we identified a full thickness macular hole (MH) that was associated with the rapid resolution of the macular edema and contraction of the CNV. After performing vitrectomy combined with CNV removal, the MH closed and her visual acuity improved. Examination of the removed CNV revealed a network of microvessels devoid of pericytes.
Conclusions and importance: The present findings suggest that rapid resolution of macular edema and contraction of the CNV and/or mild increase in the vitreous traction after anti-VEGF therapy could potentially cause MH. CNV removal via the MH may be an acceptable procedure, if the MH remains open, the CNV is of the classic type, and it spares a central portion of the fovea. |
| first_indexed | 2024-12-20T03:46:51Z |
| format | Article |
| id | doaj.art-bbd2266b93084875bdba4a85507df9e6 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-20T03:46:51Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-bbd2266b93084875bdba4a85507df9e62022-12-21T19:54:36ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362018-03-019C141710.1016/j.ajoc.2017.12.003Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degenerationAkira Hirata0Ken Hayashi1Kazuhisa Murata2Kei-ichiro Nakamura3Hayashi Eye Hospital, Fukuoka, JapanHayashi Eye Hospital, Fukuoka, JapanDepartment of Ophthalmology, Saga University Faculty of Medicine, Saga, JapanDivision of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, JapanPurpose: The formation of macular hole after receiving anti-vascular endothelial growth factor (anti-VEGF) therapy is rare. We report a case of macular hole that occurred after intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD) in a patient, who underwent vitrectomy combined with choroidal neovascularization (CNV) removal. Observations: A 64-year-old female with AMD affecting her right eye received an intravitreal injection of an anti-VEGF agent. After treatment, we identified a full thickness macular hole (MH) that was associated with the rapid resolution of the macular edema and contraction of the CNV. After performing vitrectomy combined with CNV removal, the MH closed and her visual acuity improved. Examination of the removed CNV revealed a network of microvessels devoid of pericytes. Conclusions and importance: The present findings suggest that rapid resolution of macular edema and contraction of the CNV and/or mild increase in the vitreous traction after anti-VEGF therapy could potentially cause MH. CNV removal via the MH may be an acceptable procedure, if the MH remains open, the CNV is of the classic type, and it spares a central portion of the fovea.http://www.sciencedirect.com/science/article/pii/S245199361730172XMacular holeVitrectomyChoroidal neovascular membraneAge-related macular degenerationFIB/SEM |
| spellingShingle | Akira Hirata Ken Hayashi Kazuhisa Murata Kei-ichiro Nakamura Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration American Journal of Ophthalmology Case Reports Macular hole Vitrectomy Choroidal neovascular membrane Age-related macular degeneration FIB/SEM |
| title | Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration |
| title_full | Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration |
| title_fullStr | Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration |
| title_full_unstemmed | Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration |
| title_short | Removal of choroidal neovascular membrane in a case of macular hole after anti-VEGF therapy for age-related macular degeneration |
| title_sort | removal of choroidal neovascular membrane in a case of macular hole after anti vegf therapy for age related macular degeneration |
| topic | Macular hole Vitrectomy Choroidal neovascular membrane Age-related macular degeneration FIB/SEM |
| url | http://www.sciencedirect.com/science/article/pii/S245199361730172X |
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