Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy
(1) Bio-electrical impedance analysis (BIA) is a rapid, simple, and noninvasive tool for evaluating the metabolic status and for assessing volume status in critically ill patients. Little is known, however, the prognostic value of body composition analysis in septic shock patients. This study assess...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/13/2917 |
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| author | Bora Chae Yo Sep Shin Seok-In Hong Sang Min Kim Youn-Jung Kim Seung Mok Ryoo Won Young Kim |
| author_facet | Bora Chae Yo Sep Shin Seok-In Hong Sang Min Kim Youn-Jung Kim Seung Mok Ryoo Won Young Kim |
| author_sort | Bora Chae |
| collection | DOAJ |
| description | (1) Bio-electrical impedance analysis (BIA) is a rapid, simple, and noninvasive tool for evaluating the metabolic status and for assessing volume status in critically ill patients. Little is known, however, the prognostic value of body composition analysis in septic shock patients. This study assessed the association between parameters by body composition analysis and mortality in patients with septic shock in the emergency department (ED). (2) Data were prospectively collected on adult patients with septic shock who underwent protocol-driven resuscitation bundle therapy between December 2019 and January 2021. The primary outcome was 30-day mortality. (3) The study included 261 patients, the average ratio of extracellular water (ECW) to total body water (TBW) was significantly higher in non-survivors than in survivors (0.414 vs. 0.401, <i>p</i> < 0.001). Multivariate analysis showed that ECW/TBW ≥ 0.41 (odds ratio (OR), 4.62; 95% confidence interval (CI), 2.31–9.26, <i>p</i> < 0.001), altered mental status (OR, 2.88; 95% CI, 1.28–6.46, <i>p</i> = 0.010), and lactate level (OR, 1.24; 95% CI, 1.12–1.37, <i>p</i> < 0.001) were significantly associated with 30-day mortality in patients with septic shock. (4) ECW/TBW ≥ 0.41 may be associated with 30-day mortality in patients with septic shock receiving protocol-driven resuscitation bundle therapy in the ED. |
| first_indexed | 2024-03-09T04:46:15Z |
| format | Article |
| id | doaj.art-bbd404f073ba4a5189480d2a336c6674 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:46:15Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bbd404f073ba4a5189480d2a336c66742023-12-03T13:16:05ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011013291710.3390/jcm10132917Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle TherapyBora Chae0Yo Sep Shin1Seok-In Hong2Sang Min Kim3Youn-Jung Kim4Seung Mok Ryoo5Won Young Kim6Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea(1) Bio-electrical impedance analysis (BIA) is a rapid, simple, and noninvasive tool for evaluating the metabolic status and for assessing volume status in critically ill patients. Little is known, however, the prognostic value of body composition analysis in septic shock patients. This study assessed the association between parameters by body composition analysis and mortality in patients with septic shock in the emergency department (ED). (2) Data were prospectively collected on adult patients with septic shock who underwent protocol-driven resuscitation bundle therapy between December 2019 and January 2021. The primary outcome was 30-day mortality. (3) The study included 261 patients, the average ratio of extracellular water (ECW) to total body water (TBW) was significantly higher in non-survivors than in survivors (0.414 vs. 0.401, <i>p</i> < 0.001). Multivariate analysis showed that ECW/TBW ≥ 0.41 (odds ratio (OR), 4.62; 95% confidence interval (CI), 2.31–9.26, <i>p</i> < 0.001), altered mental status (OR, 2.88; 95% CI, 1.28–6.46, <i>p</i> = 0.010), and lactate level (OR, 1.24; 95% CI, 1.12–1.37, <i>p</i> < 0.001) were significantly associated with 30-day mortality in patients with septic shock. (4) ECW/TBW ≥ 0.41 may be associated with 30-day mortality in patients with septic shock receiving protocol-driven resuscitation bundle therapy in the ED.https://www.mdpi.com/2077-0383/10/13/2917septic shockbody fluid compositionbio-electrical impedance analysisECW/TBWmortality |
| spellingShingle | Bora Chae Yo Sep Shin Seok-In Hong Sang Min Kim Youn-Jung Kim Seung Mok Ryoo Won Young Kim Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy Journal of Clinical Medicine septic shock body fluid composition bio-electrical impedance analysis ECW/TBW mortality |
| title | Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy |
| title_full | Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy |
| title_fullStr | Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy |
| title_full_unstemmed | Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy |
| title_short | Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy |
| title_sort | extracellular water to total body water ratio in septic shock patients receiving protocol driven resuscitation bundle therapy |
| topic | septic shock body fluid composition bio-electrical impedance analysis ECW/TBW mortality |
| url | https://www.mdpi.com/2077-0383/10/13/2917 |
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