Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review
Idiopathic CD4 lymphocytopenia (ICL), also known as non-HIV AIDS, is a rare disease characterized by opportunistic infections, malignancies, and autoimmune diseases. Idiopathic CD4 lymphocytopenia is defined as CD4+ T-lymphocyte level below 300/mm3 in at least two measurements or less than 20% of to...
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Format: | Article |
Language: | Turkish |
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Galenos Yayinevi
2019-12-01
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Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
Subjects: | |
Online Access: | http://mjima.org/text.php?&id=180 |
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author | Firdevs AKSOY Murat AYDIN Gürdal YILMAZ Ali Rıza GÜVERCİN İlker EYÜBOĞLU Ahmet SARI Gülçin BAYRAMOĞLU İftihar KÖKSAL |
author_facet | Firdevs AKSOY Murat AYDIN Gürdal YILMAZ Ali Rıza GÜVERCİN İlker EYÜBOĞLU Ahmet SARI Gülçin BAYRAMOĞLU İftihar KÖKSAL |
author_sort | Firdevs AKSOY |
collection | DOAJ |
description | Idiopathic CD4 lymphocytopenia (ICL), also known as non-HIV AIDS, is a rare disease characterized by opportunistic infections, malignancies, and autoimmune diseases. Idiopathic CD4 lymphocytopenia is defined as CD4+ T-lymphocyte level below 300/mm3 in at least two measurements or less than 20% of total lymphocytes, which cannot be explained by any other condition, including HIV infection. Nocardia spp. are opportunistic microorganisms that is a frequent cause of infection in immunocompromised individuals. In this paper, we report a 50-year-old patient with ICL and intracranial brain abscess due to Nocardia farcinica and review th literature for related articles published between April 2012 and December 2018. These data suggest that there may be an underlying immunosuppression in adult patients who have infections that are recurrent, refractory, and caused by opportunistic pathogens. |
first_indexed | 2024-04-10T11:33:30Z |
format | Article |
id | doaj.art-bbd5614d020c4c65a575d427d6ae5454 |
institution | Directory Open Access Journal |
issn | 2147-673X |
language | Turkish |
last_indexed | 2024-04-10T11:33:30Z |
publishDate | 2019-12-01 |
publisher | Galenos Yayinevi |
record_format | Article |
series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
spelling | doaj.art-bbd5614d020c4c65a575d427d6ae54542023-02-15T16:17:58ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2019-12-01810.4274/mjima.galenos.2019.2019.24Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature ReviewFirdevs AKSOY0https://orcid.org/0000-0002-1926-1273Murat AYDIN1https://orcid.org/0000-0002-0167-0802Gürdal YILMAZ2https://orcid.org/0000-0002-5967-9615Ali Rıza GÜVERCİN3https://orcid.org/0000-0002-8689-0571İlker EYÜBOĞLU4https://orcid.org/0000-0002-7732-1289Ahmet SARI5https://orcid.org/0000-0002-6959-8771Gülçin BAYRAMOĞLU6https://orcid.org/0000-0002-6103-3127İftihar KÖKSAL7https://orcid.org/0000-0003-4892-8935Karadeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Neurosurgery, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Radiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Radiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Medical Microbiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TurkeyIdiopathic CD4 lymphocytopenia (ICL), also known as non-HIV AIDS, is a rare disease characterized by opportunistic infections, malignancies, and autoimmune diseases. Idiopathic CD4 lymphocytopenia is defined as CD4+ T-lymphocyte level below 300/mm3 in at least two measurements or less than 20% of total lymphocytes, which cannot be explained by any other condition, including HIV infection. Nocardia spp. are opportunistic microorganisms that is a frequent cause of infection in immunocompromised individuals. In this paper, we report a 50-year-old patient with ICL and intracranial brain abscess due to Nocardia farcinica and review th literature for related articles published between April 2012 and December 2018. These data suggest that there may be an underlying immunosuppression in adult patients who have infections that are recurrent, refractory, and caused by opportunistic pathogens.http://mjima.org/text.php?&id=180t-lymphocytopeniaidiopathic cd4-positiverare diseasesnocardianocardiosis |
spellingShingle | Firdevs AKSOY Murat AYDIN Gürdal YILMAZ Ali Rıza GÜVERCİN İlker EYÜBOĞLU Ahmet SARI Gülçin BAYRAMOĞLU İftihar KÖKSAL Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review Mediterranean Journal of Infection, Microbes and Antimicrobials t-lymphocytopenia idiopathic cd4-positive rare diseases nocardia nocardiosis |
title | Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review |
title_full | Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review |
title_fullStr | Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review |
title_full_unstemmed | Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review |
title_short | Idiopathic CD4 Lymphocytopenia (HIV-Negative AIDS): Case Report and Literature Review |
title_sort | idiopathic cd4 lymphocytopenia hiv negative aids case report and literature review |
topic | t-lymphocytopenia idiopathic cd4-positive rare diseases nocardia nocardiosis |
url | http://mjima.org/text.php?&id=180 |
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