Migraine, Allergy, and Histamine: Is There a Link?
The relationship between migraines and allergies is controversial. Though they are epidemiologically linked, the underlying pathophysiological connection between them remains unclear. Migraines and allergic disorders have various underlying genetic and biological causes. As per the literature, these...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/10/3566 |
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| author | Alessandro Ferretti Mattia Gatto Margherita Velardi Giovanni Di Nardo Thomas Foiadelli Gianluca Terrin Manuela Cecili Umberto Raucci Massimiliano Valeriani Pasquale Parisi |
| author_facet | Alessandro Ferretti Mattia Gatto Margherita Velardi Giovanni Di Nardo Thomas Foiadelli Gianluca Terrin Manuela Cecili Umberto Raucci Massimiliano Valeriani Pasquale Parisi |
| author_sort | Alessandro Ferretti |
| collection | DOAJ |
| description | The relationship between migraines and allergies is controversial. Though they are epidemiologically linked, the underlying pathophysiological connection between them remains unclear. Migraines and allergic disorders have various underlying genetic and biological causes. As per the literature, these conditions are epidemiologically linked, and some common pathophysiological pathways have been hypothesized. The histaminergic system may be the clue to understanding the correlation among these diseases. As a neurotransmitter in the central nervous system with a vasodilatory effect, histamine has a well-documented influence on the allergic response and could be involved in the pathophysiology of migraines. Histamine may influence hypothalamic activity, which may play a major role in migraines or may simply influence their severity. In both cases, antihistamine drugs could prove useful. This review examines whether the histaminergic system, particularly H3 and H4 receptors, may provide a mechanistic link between the pathophysiology of migraines and allergic disorders, two common and debilitating conditions. Identifying their connection could help identify novel therapeutic strategies. |
| first_indexed | 2024-03-11T03:37:51Z |
| format | Article |
| id | doaj.art-bbd79447d3ce44adad3a8ccf58b842ff |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:37:51Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bbd79447d3ce44adad3a8ccf58b842ff2023-11-18T01:55:12ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011210356610.3390/jcm12103566Migraine, Allergy, and Histamine: Is There a Link?Alessandro Ferretti0Mattia Gatto1Margherita Velardi2Giovanni Di Nardo3Thomas Foiadelli4Gianluca Terrin5Manuela Cecili6Umberto Raucci7Massimiliano Valeriani8Pasquale Parisi9Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, ItalyChild Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, 00133 Rome, ItalyGeneral and Emergency Department, Bambino Gesù Children’s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, ItalyPediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, ItalyPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyDepartment of Mother and Child, Gynecological and Urological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185 Rome, ItalyPediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, ItalyGeneral and Emergency Department, Bambino Gesù Children’s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, ItalyDevelopmental Neurology Unit, Bambino Gesù Children’s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, ItalyPediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, ItalyThe relationship between migraines and allergies is controversial. Though they are epidemiologically linked, the underlying pathophysiological connection between them remains unclear. Migraines and allergic disorders have various underlying genetic and biological causes. As per the literature, these conditions are epidemiologically linked, and some common pathophysiological pathways have been hypothesized. The histaminergic system may be the clue to understanding the correlation among these diseases. As a neurotransmitter in the central nervous system with a vasodilatory effect, histamine has a well-documented influence on the allergic response and could be involved in the pathophysiology of migraines. Histamine may influence hypothalamic activity, which may play a major role in migraines or may simply influence their severity. In both cases, antihistamine drugs could prove useful. This review examines whether the histaminergic system, particularly H3 and H4 receptors, may provide a mechanistic link between the pathophysiology of migraines and allergic disorders, two common and debilitating conditions. Identifying their connection could help identify novel therapeutic strategies.https://www.mdpi.com/2077-0383/12/10/3566migraineallergyallergic disordershistamineantihistamine drugshistaminergic system |
| spellingShingle | Alessandro Ferretti Mattia Gatto Margherita Velardi Giovanni Di Nardo Thomas Foiadelli Gianluca Terrin Manuela Cecili Umberto Raucci Massimiliano Valeriani Pasquale Parisi Migraine, Allergy, and Histamine: Is There a Link? Journal of Clinical Medicine migraine allergy allergic disorders histamine antihistamine drugs histaminergic system |
| title | Migraine, Allergy, and Histamine: Is There a Link? |
| title_full | Migraine, Allergy, and Histamine: Is There a Link? |
| title_fullStr | Migraine, Allergy, and Histamine: Is There a Link? |
| title_full_unstemmed | Migraine, Allergy, and Histamine: Is There a Link? |
| title_short | Migraine, Allergy, and Histamine: Is There a Link? |
| title_sort | migraine allergy and histamine is there a link |
| topic | migraine allergy allergic disorders histamine antihistamine drugs histaminergic system |
| url | https://www.mdpi.com/2077-0383/12/10/3566 |
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