Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity
Background: The hepatotoxic effect of 5-fluorouracil (5-FU) can deprive cancer patients of its maximum therapeutic benefits. Selenium (Se) is a trace element with potential benefits in some animal models of diseases. Objectives: This study assessed the ability of Se to nullify the hepatotoxic effec...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-09-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-298-en.html |
| _version_ | 1828970137111232512 |
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| author | Elias Adikwu Nelson Clemente Ebinyo |
| author_facet | Elias Adikwu Nelson Clemente Ebinyo |
| author_sort | Elias Adikwu |
| collection | DOAJ |
| description | Background: The hepatotoxic effect of 5-fluorouracil (5-FU) can deprive cancer patients of its maximum therapeutic benefits. Selenium (Se) is a trace element with potential benefits in some animal models of diseases.
Objectives: This study assessed the ability of Se to nullify the hepatotoxic effect of 5-FU in albino rats.
Methods: In this study, 40 adult male albino rats were grouped into A to D (each 5 rats). Rats in group A (control) were treated intraperitoneally (IP) with normal saline (0.2 mL) daily for 5 days. Rats in groups B1 to B3 were treated IP with Se (0.125, 0.25, and 0.50 mg/kg) daily for 5 days, respectively. Rats in group C were treated IP with 5-FU (20 mg/kg) daily for 5 days. Rats in groups D1to D3 were treated IP with Se with 0.125, 0.25, and 0.50 mg/kg before treatment with 5-FU (20 mg/kg) daily for 5 days, respectively. After treatment, the rats were euthanized, and their blood samples were collected and evaluated for serum liver function. Liver samples were evaluated for biochemical and histological parameters.
Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P<0.001) high in 5-FU-treated rats in comparison to the control group. Liver glutathione peroxidase, superoxide dismutase (SOD), catalase, and glutathione levels were significantly (P<0.001) low whereas the malondialdehyde level was significantly (P<0.001) high in 5-FU-treated rats compared with the control group. Moreover, hepatocyte necrosis was observed in 5-FU-treated rats.
Conclusion: Nonetheless, 5-FU-induced hepatotoxicity was significantly nullified in rats supplemented with Se (0.125 mg/kg, P<0.05; 0.25 mg/kg, P<0.01, and 0.5 mg/kg, P<0.001) in a dose-dependent fashion in comparison to 5-FU-treated rats. Thus, Se may have a clinical benefit in 5-FU-induced hepatotoxicity |
| first_indexed | 2024-12-14T12:44:40Z |
| format | Article |
| id | doaj.art-bbda140432ca4a6289ca10d601c84fb4 |
| institution | Directory Open Access Journal |
| issn | 2423-4494 |
| language | English |
| last_indexed | 2024-12-14T12:44:40Z |
| publishDate | 2020-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-bbda140432ca4a6289ca10d601c84fb42022-12-21T23:00:49ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942020-09-016319720410.18502/pbr.v6i3.4646Selenium Safeguards the Liver Against 5-Fluorouracil Induced ToxicityElias Adikwu0https://orcid.org/0000-0003-4349-8227 Nelson Clemente Ebinyo1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Amassama, NigeriaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Amassama, NigeriaBackground: The hepatotoxic effect of 5-fluorouracil (5-FU) can deprive cancer patients of its maximum therapeutic benefits. Selenium (Se) is a trace element with potential benefits in some animal models of diseases. Objectives: This study assessed the ability of Se to nullify the hepatotoxic effect of 5-FU in albino rats. Methods: In this study, 40 adult male albino rats were grouped into A to D (each 5 rats). Rats in group A (control) were treated intraperitoneally (IP) with normal saline (0.2 mL) daily for 5 days. Rats in groups B1 to B3 were treated IP with Se (0.125, 0.25, and 0.50 mg/kg) daily for 5 days, respectively. Rats in group C were treated IP with 5-FU (20 mg/kg) daily for 5 days. Rats in groups D1to D3 were treated IP with Se with 0.125, 0.25, and 0.50 mg/kg before treatment with 5-FU (20 mg/kg) daily for 5 days, respectively. After treatment, the rats were euthanized, and their blood samples were collected and evaluated for serum liver function. Liver samples were evaluated for biochemical and histological parameters. Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P<0.001) high in 5-FU-treated rats in comparison to the control group. Liver glutathione peroxidase, superoxide dismutase (SOD), catalase, and glutathione levels were significantly (P<0.001) low whereas the malondialdehyde level was significantly (P<0.001) high in 5-FU-treated rats compared with the control group. Moreover, hepatocyte necrosis was observed in 5-FU-treated rats. Conclusion: Nonetheless, 5-FU-induced hepatotoxicity was significantly nullified in rats supplemented with Se (0.125 mg/kg, P<0.05; 0.25 mg/kg, P<0.01, and 0.5 mg/kg, P<0.001) in a dose-dependent fashion in comparison to 5-FU-treated rats. Thus, Se may have a clinical benefit in 5-FU-induced hepatotoxicityhttp://pbr.mazums.ac.ir/article-1-298-en.html5-fluorouracilliver chemotherapytoxicityseleniumprotectionantioxidant |
| spellingShingle | Elias Adikwu Nelson Clemente Ebinyo Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity Pharmaceutical and Biomedical Research 5-fluorouracil liver chemotherapy toxicity selenium protection antioxidant |
| title | Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity |
| title_full | Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity |
| title_fullStr | Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity |
| title_full_unstemmed | Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity |
| title_short | Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity |
| title_sort | selenium safeguards the liver against 5 fluorouracil induced toxicity |
| topic | 5-fluorouracil liver chemotherapy toxicity selenium protection antioxidant |
| url | http://pbr.mazums.ac.ir/article-1-298-en.html |
| work_keys_str_mv | AT eliasadikwu seleniumsafeguardstheliveragainst5fluorouracilinducedtoxicity AT nelsonclementeebinyo seleniumsafeguardstheliveragainst5fluorouracilinducedtoxicity |