Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Abstract Background Trans-differentiation of human-induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons a likely significant advance for disease modeling and in vitro assay development. Recent single-cell interrogation of...

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Bibliographic Details
Main Authors: D. Das, S. Sonthalia, G. Stein-O.’Brien, MH. Wahbeh, K. Feuer, L. Goff, C. Colantuoni, V. Mahairaki, D. Avramopoulos
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Biology
Subjects:
Schizophrenia
Autism
Alzheimer’s
Transcriptome
Single cell
Induced pluripotent stem cells
Online Access:https://doi.org/10.1186/s12915-024-01867-4

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