Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also known as kisspeptin/neurokinin B/dynorphin (K...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.958377/full |
| _version_ | 1811310196822114304 |
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| author | Yoshihisa Uenoyama Hitomi Tsuchida Mayuko Nagae Naoko Inoue Hiroko Tsukamura |
| author_facet | Yoshihisa Uenoyama Hitomi Tsuchida Mayuko Nagae Naoko Inoue Hiroko Tsukamura |
| author_sort | Yoshihisa Uenoyama |
| collection | DOAJ |
| description | Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also known as kisspeptin/neurokinin B/dynorphin (KNDy) neurons, play a role as a master regulator of pulsatile gonadotropin-releasing hormone (GnRH) release in mammals. In this study, we first focus on the role of dynorphin released by KNDy neurons in the GnRH pulse generation. Second, we provide a historical overview of studies on endogenous opioid peptides. Third, we discuss how endogenous opioid peptides modulate tonic GnRH/gonadotropin release in female mammals as a mediator of inhibitory internal and external cues, such as ovarian steroids, nutritional status, or stress, on reproduction. Then, we discuss the role of endogenous opioid peptides in GnRH surge generation in female mammals. |
| first_indexed | 2024-04-13T09:55:07Z |
| format | Article |
| id | doaj.art-bbdbec7b087f45f3b314784477d6d250 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T09:55:07Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-bbdbec7b087f45f3b314784477d6d2502022-12-22T02:51:28ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-08-011610.3389/fnins.2022.958377958377Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammalsYoshihisa UenoyamaHitomi TsuchidaMayuko NagaeNaoko InoueHiroko TsukamuraEndogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also known as kisspeptin/neurokinin B/dynorphin (KNDy) neurons, play a role as a master regulator of pulsatile gonadotropin-releasing hormone (GnRH) release in mammals. In this study, we first focus on the role of dynorphin released by KNDy neurons in the GnRH pulse generation. Second, we provide a historical overview of studies on endogenous opioid peptides. Third, we discuss how endogenous opioid peptides modulate tonic GnRH/gonadotropin release in female mammals as a mediator of inhibitory internal and external cues, such as ovarian steroids, nutritional status, or stress, on reproduction. Then, we discuss the role of endogenous opioid peptides in GnRH surge generation in female mammals.https://www.frontiersin.org/articles/10.3389/fnins.2022.958377/fullendogenous opioid peptidesdynorphinβ-endorphinenkephalinGnRH pulse generatorGnRH surge generator |
| spellingShingle | Yoshihisa Uenoyama Hitomi Tsuchida Mayuko Nagae Naoko Inoue Hiroko Tsukamura Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals Frontiers in Neuroscience endogenous opioid peptides dynorphin β-endorphin enkephalin GnRH pulse generator GnRH surge generator |
| title | Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| title_full | Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| title_fullStr | Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| title_full_unstemmed | Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| title_short | Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| title_sort | opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals |
| topic | endogenous opioid peptides dynorphin β-endorphin enkephalin GnRH pulse generator GnRH surge generator |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.958377/full |
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