Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis
Background/Aim: Dehiscence of the colorectal anastomosis is one of the most serious complications in digestive surgery that is still present in a large percentage today, which significantly increases the cost of treatment and can lead to death. Due to all the above, early detection of anastomotic de...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2022-01-01
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| Series: | Scripta Medica |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2022/2490-33292202140Q.pdf |
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| author | Đeri Jugoslav Ćulum Jovan Aleksić Zoran Šaran Dalibor Rajić Romana |
| author_facet | Đeri Jugoslav Ćulum Jovan Aleksić Zoran Šaran Dalibor Rajić Romana |
| author_sort | Đeri Jugoslav |
| collection | DOAJ |
| description | Background/Aim: Dehiscence of the colorectal anastomosis is one of the most serious complications in digestive surgery that is still present in a large percentage today, which significantly increases the cost of treatment and can lead to death. Due to all the above, early detection of anastomotic dehiscence is very important, as well as the decision on surgical treatment. Procalcitonin (PCT) is thought to be an important marker of inflammation and sepsis. Aim of this paper was to confirm PCT as a marker of great sensitivity in early diagnosis of anastomotic leakage. Methods: The study included patients who underwent surgery for colorectal cancer in the period from 2016 to 2020. Patients were operated according to an elective protocol and with an open surgical approach. In patients, PCT values were measured on the 2nd and 4th postoperative day (POD) to determine the association between elevated PCT values and the onset of dehiscence of the colorectal anastomosis. Results: A study was conducted in 118 patients in whom a stapler colorectal anastomosis was created. Colorectal anastomosis dehiscence occurred in 10 patients. In 4 patients with dehiscence, no re-surgical intervention was required, but they were taken care of by conservative methods. Repeated surgery was performed in 6 patients. In all patients with dehiscence, there was a multiple increase in the value of PCT above normal. Conclusion: PCT has high sensitivity and specificity (85 and 74 % respectively) as a marker in dehiscence of colorectal anastomosis. In this study it was found that PCT values were significantly correlated with the dehiscence of anastomo-sis 2nd POD and especially 4th POD. |
| first_indexed | 2024-12-10T08:55:19Z |
| format | Article |
| id | doaj.art-bbddb5bc5d0047388a0bf18f88cd0ae8 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-12-10T08:55:19Z |
| publishDate | 2022-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-bbddb5bc5d0047388a0bf18f88cd0ae82022-12-22T01:55:26ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542022-01-0153214014410.5937/scriptamed53-355442490-33292202140QProcalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosisĐeri Jugoslav0Ćulum Jovan1Aleksić Zoran2Šaran Dalibor3Rajić Romana4University Clinical Centre of the Republic of Srpska, Department of General and Abdominal Surgery, Banja Luka, the Republic of Srpska, Bosnia and HerzegovinaClinic 'S-tetik' Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre of the Republic of Srpska, Department of General and Abdominal Surgery, Banja Luka, the Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre of the Republic of Srpska, Department of General and Abdominal Surgery, Banja Luka, the Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre, Clinic for Internal Diseases, Department of Gastroenterohepatology, Banja Luka, the Republic of Srpska, Bosnia and HerzegovinaBackground/Aim: Dehiscence of the colorectal anastomosis is one of the most serious complications in digestive surgery that is still present in a large percentage today, which significantly increases the cost of treatment and can lead to death. Due to all the above, early detection of anastomotic dehiscence is very important, as well as the decision on surgical treatment. Procalcitonin (PCT) is thought to be an important marker of inflammation and sepsis. Aim of this paper was to confirm PCT as a marker of great sensitivity in early diagnosis of anastomotic leakage. Methods: The study included patients who underwent surgery for colorectal cancer in the period from 2016 to 2020. Patients were operated according to an elective protocol and with an open surgical approach. In patients, PCT values were measured on the 2nd and 4th postoperative day (POD) to determine the association between elevated PCT values and the onset of dehiscence of the colorectal anastomosis. Results: A study was conducted in 118 patients in whom a stapler colorectal anastomosis was created. Colorectal anastomosis dehiscence occurred in 10 patients. In 4 patients with dehiscence, no re-surgical intervention was required, but they were taken care of by conservative methods. Repeated surgery was performed in 6 patients. In all patients with dehiscence, there was a multiple increase in the value of PCT above normal. Conclusion: PCT has high sensitivity and specificity (85 and 74 % respectively) as a marker in dehiscence of colorectal anastomosis. In this study it was found that PCT values were significantly correlated with the dehiscence of anastomo-sis 2nd POD and especially 4th POD.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2022/2490-33292202140Q.pdfcolorectal anastomosisanastomotic dehiscenceprocalcitonin |
| spellingShingle | Đeri Jugoslav Ćulum Jovan Aleksić Zoran Šaran Dalibor Rajić Romana Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis Scripta Medica colorectal anastomosis anastomotic dehiscence procalcitonin |
| title | Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| title_full | Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| title_fullStr | Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| title_full_unstemmed | Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| title_short | Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| title_sort | procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis |
| topic | colorectal anastomosis anastomotic dehiscence procalcitonin |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2022/2490-33292202140Q.pdf |
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