Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study
<p>Abstract</p> <p>Background</p> <p>Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) of patients with breast (BC) and colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focus...
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | http://www.hqlo.com/content/9/1/85 |
| _version_ | 1818526197270708224 |
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| author | Bockelbrink Angelina Feder Gene Zerm Roland Büssing Arndt Reif Marcus Kröz Matthias von Laue Hans Matthes H Harald Willich Stefan N Girke Matthias |
| author_facet | Bockelbrink Angelina Feder Gene Zerm Roland Büssing Arndt Reif Marcus Kröz Matthias von Laue Hans Matthes H Harald Willich Stefan N Girke Matthias |
| author_sort | Bockelbrink Angelina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) of patients with breast (BC) and colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focusing on adaptive characteristics such as sense of coherence or self-regulation, which could be more appropriate as a prognostic tool than classical HRQL. The aim of this study was to assess the association of autonomic regulation (aR) and self-regulation (SR) with survival.</p> <p>Methods</p> <p>146 cancer patients and 120 healthy controls took part in an initial evaluation in 2000/2001. At a median follow up of 5.9 years later, 62 of 95 BC, 17 of 51 CRC patients, and 85 of 117 healthy controls took part in the follow-up study. 41 participants had died. For the follow-up evaluation, participants were requested to complete the standardized aR and SR questionnaires.</p> <p>Results</p> <p>On average, cancer patients had survived for 10.1 years with the disease. Using a Cox proportional hazard regression with stepwise variables such as age, diagnosis group, Charlson co-morbidity index, body mass index (BMI)) aR and SR. SR were identified as independent parameters with potential prognostic relevance on survival While aR did not significantly influence survival, SR showed a positive and independent impact on survival (OR = 0.589; 95%-CI: 0.354 - 0.979). This positive effect persisted significantly in the sensitivity analysis of the subgroup of tumour patients and in the subscale 'Achieve satisfaction and well-being' and by tendency in the UICC stages nested for the different diagnoses groups.</p> <p>Conclusions</p> <p>Self-regulation might be an independent prognostic factor for the survival of breast and colon carcinoma patients and merits further prospective studies.</p> |
| first_indexed | 2024-12-11T06:19:35Z |
| format | Article |
| id | doaj.art-bbddc61adc934ef587a2d4a7b1adaed8 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-12-11T06:19:35Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-bbddc61adc934ef587a2d4a7b1adaed82022-12-22T01:17:51ZengBMCHealth and Quality of Life Outcomes1477-75252011-09-01918510.1186/1477-7525-9-85Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome studyBockelbrink AngelinaFeder GeneZerm RolandBüssing ArndtReif MarcusKröz Matthiasvon Laue HansMatthes H HaraldWillich Stefan NGirke Matthias<p>Abstract</p> <p>Background</p> <p>Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) of patients with breast (BC) and colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focusing on adaptive characteristics such as sense of coherence or self-regulation, which could be more appropriate as a prognostic tool than classical HRQL. The aim of this study was to assess the association of autonomic regulation (aR) and self-regulation (SR) with survival.</p> <p>Methods</p> <p>146 cancer patients and 120 healthy controls took part in an initial evaluation in 2000/2001. At a median follow up of 5.9 years later, 62 of 95 BC, 17 of 51 CRC patients, and 85 of 117 healthy controls took part in the follow-up study. 41 participants had died. For the follow-up evaluation, participants were requested to complete the standardized aR and SR questionnaires.</p> <p>Results</p> <p>On average, cancer patients had survived for 10.1 years with the disease. Using a Cox proportional hazard regression with stepwise variables such as age, diagnosis group, Charlson co-morbidity index, body mass index (BMI)) aR and SR. SR were identified as independent parameters with potential prognostic relevance on survival While aR did not significantly influence survival, SR showed a positive and independent impact on survival (OR = 0.589; 95%-CI: 0.354 - 0.979). This positive effect persisted significantly in the sensitivity analysis of the subgroup of tumour patients and in the subscale 'Achieve satisfaction and well-being' and by tendency in the UICC stages nested for the different diagnoses groups.</p> <p>Conclusions</p> <p>Self-regulation might be an independent prognostic factor for the survival of breast and colon carcinoma patients and merits further prospective studies.</p>http://www.hqlo.com/content/9/1/85Autonomic regulation (aR)breast cancercolorectal cancercopingself-regulation (SR) |
| spellingShingle | Bockelbrink Angelina Feder Gene Zerm Roland Büssing Arndt Reif Marcus Kröz Matthias von Laue Hans Matthes H Harald Willich Stefan N Girke Matthias Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study Health and Quality of Life Outcomes Autonomic regulation (aR) breast cancer colorectal cancer coping self-regulation (SR) |
| title | Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study |
| title_full | Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study |
| title_fullStr | Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study |
| title_full_unstemmed | Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study |
| title_short | Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study |
| title_sort | does self regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients results of a prospective outcome study |
| topic | Autonomic regulation (aR) breast cancer colorectal cancer coping self-regulation (SR) |
| url | http://www.hqlo.com/content/9/1/85 |
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