Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021

Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021

Abstract Background Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemisinin-based combination therapy (ACT). This study assessed the trends of molecular markers of artemisi...

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Main Authors: Catherine Bakari, Celine I. Mandara, Rashid A. Madebe, Misago D. Seth, Billy Ngasala, Erasmus Kamugisha, Maimuna Ahmed, Filbert Francis, Samwel Bushukatale, Mercy Chiduo, Twilumba Makene, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Reginald A. Kavishe, Florida Muro, Sigsbert Mkude, Renata Mandike, Fabrizio Molteni, Frank Chacky, Dunstan R. Bishanga, Ritha J. A. Njau, Marian Warsame, Bilali Kabula, Ssanyu S. Nyinondi, Naomi W. Lucchi, Eldin Talundzic, Meera Venkatesan, Leah F. Moriarty, Naomi Serbantez, Chonge Kitojo, Erik J. Reaves, Eric S. Halsey, Ally Mohamed, Venkatachalam Udhayakumar, Deus S. Ishengoma
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Malaria Journal
Subjects:
Malaria
Molecular markers
Therapeutic efficacy studies
Plasmodium falciparum kelch 13 (k13)
Plasmodium falciparum multidrug resistance 1 (pfmdr1)
Plasmodium falciparum
Online Access:https://doi.org/10.1186/s12936-024-04896-0

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