Hydrolysis of Ibuprofen Nitrile and Ibuprofen Amide and Deracemisation of Ibuprofen Using Nocardia corallina B-276

Hydrolysis of Ibuprofen Nitrile and Ibuprofen Amide and Deracemisation of Ibuprofen Using Nocardia corallina B-276

A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells in a potassium phosphate buffer solution (0.1...

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Bibliographic Details
Main Authors: Myrna Solís-Oba, Norberto Manjarrez, Aida Solís, Ricardo Lievano, Herminia Inés Pérez
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
Nocardia corallina
deracemisation
ibuprofen
nitrile hydratase
amidase
Online Access:http://www.mdpi.com/1420-3049/17/3/3148/

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