Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota
Residual antibiotics may affect human health by increasing challenges related to infection treatment due to antibiotic resistance development. Hence, determining whether residual antibiotics in the body can lead to antibiotic resistance is important. We developed a model to predict possible antibiot...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023033352 |
| _version_ | 1797815593627287552 |
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| author | Seung Yun Lee Da Young Lee Hea Jin Kang Seung Hyeon Yun Ermie Jr. Mariano Juhyun Lee Jong Hyuk Kim Sun Jin Hur |
| author_facet | Seung Yun Lee Da Young Lee Hea Jin Kang Seung Hyeon Yun Ermie Jr. Mariano Juhyun Lee Jong Hyuk Kim Sun Jin Hur |
| author_sort | Seung Yun Lee |
| collection | DOAJ |
| description | Residual antibiotics may affect human health by increasing challenges related to infection treatment due to antibiotic resistance development. Hence, determining whether residual antibiotics in the body can lead to antibiotic resistance is important. We developed a model to predict possible antibiotic resistance caused by residual antibiotics by simulating human digestion in vitro. Increased antibiotic resistance was found to be dependent on the digestion process. Ethical prediction of antibiotic resistance using fewer animals and no humans was possible by simulating the internal environment. Thus, preliminary studies to monitor antibiotic resistance that can affect human health may be safely conducted using this model. |
| first_indexed | 2024-03-13T08:25:09Z |
| format | Article |
| id | doaj.art-bbe43a0335c24812ae3f17f16810a1d3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:09Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-bbe43a0335c24812ae3f17f16810a1d32023-05-31T04:46:43ZengElsevierHeliyon2405-84402023-05-0195e16128Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiotaSeung Yun Lee0Da Young Lee1Hea Jin Kang2Seung Hyeon Yun3Ermie Jr. Mariano4Juhyun Lee5Jong Hyuk Kim6Sun Jin Hur7Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju, 52725, South Korea; Institute of Agriculture & Life Science, Gyeongsang National University, Jinju, 52725, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South KoreaDepartment of Animal Science, Chungbuk National University, Cheongju, 28644, South KoreaDepartment of Animal Science and Technology, Chung-Ang University, Anseong, 17546, South Korea; Corresponding author.Residual antibiotics may affect human health by increasing challenges related to infection treatment due to antibiotic resistance development. Hence, determining whether residual antibiotics in the body can lead to antibiotic resistance is important. We developed a model to predict possible antibiotic resistance caused by residual antibiotics by simulating human digestion in vitro. Increased antibiotic resistance was found to be dependent on the digestion process. Ethical prediction of antibiotic resistance using fewer animals and no humans was possible by simulating the internal environment. Thus, preliminary studies to monitor antibiotic resistance that can affect human health may be safely conducted using this model.http://www.sciencedirect.com/science/article/pii/S2405844023033352In vitro human digestionGut microbiotaAntibiotic resistance |
| spellingShingle | Seung Yun Lee Da Young Lee Hea Jin Kang Seung Hyeon Yun Ermie Jr. Mariano Juhyun Lee Jong Hyuk Kim Sun Jin Hur Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota Heliyon In vitro human digestion Gut microbiota Antibiotic resistance |
| title | Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| title_full | Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| title_fullStr | Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| title_full_unstemmed | Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| title_short | Analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| title_sort | analysis of changes in antibiotic resistance in the human body using an in vitro digestion model incorporating human gut microbiota |
| topic | In vitro human digestion Gut microbiota Antibiotic resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023033352 |
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